Document Detail


The isolated perfused rat heart: a model for studying myocardial hypoxia or ischaemia.
MedLine Citation:
PMID:  6332619     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of this paper is to consider the advantages of using isolated heart preparations in studies designed to investigate the effect of hypoxia or ischaemia on myocardial cells. After a brief description of the two most frequently used experimental models of perfused hearts, namely the Langendorff preparation and the working heart preparation, some of the various methods used to induce hypoxia or ischaemia are described, as well as some of the possible techniques allowing to assess metabolic alterations occurring in these pathological situations. After discussing the limitations and advantages specific to the Langendorff and working heart preparations, the suitability of isolated heart models in studies on myocardial protection is then considered. To illustrate this point, the effect of intravenous administration of the slow calcium channel blocker bepridil (5 mg X kg-1) on post-ischaemic recovery of cardiac function and metabolism after global normothermic ischaemia of the isolated heart is reported. It is concluded that isolated heart preparations allow a fine control of experimental conditions with the advantage that functional and metabolic measurements can be easily made.
Authors:
J de Leiris; D P Harding; S Pestre
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Basic research in cardiology     Volume:  79     ISSN:  0300-8428     ISO Abbreviation:  Basic Res. Cardiol.     Publication Date:    1984 May-Jun
Date Detail:
Created Date:  1984-10-18     Completed Date:  1984-10-18     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0360342     Medline TA:  Basic Res Cardiol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  313-21     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Bepridil
Calcium Channel Blockers / pharmacology
Coronary Disease / metabolism*
Energy Metabolism / drug effects
Glycogen / metabolism
Hemodynamics / drug effects
Lactates / metabolism
Lactic Acid
Models, Cardiovascular
Myocardial Contraction* / drug effects
Myocardial Infarction / metabolism
Myocardium / metabolism*
NAD / metabolism
Oxygen Consumption / drug effects
Perfusion
Pyrrolidines / pharmacology
Rats
Chemical
Reg. No./Substance:
0/Calcium Channel Blockers; 0/Lactates; 0/Pyrrolidines; 50-21-5/Lactic Acid; 53-84-9/NAD; 64706-54-3/Bepridil; 9005-79-2/Glycogen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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