| The isolated hypertensive lower oesophageal sphincter: audit in a specialist unit. | |
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MedLine Citation:
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PMID: 11133054 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The hypertensive lower oesophageal sphincter (HLOS) is a distinct clinical entity defined by a lower oesophageal sphincter (LOS) pressure > or = 30mmHg and normal LOS relaxation and oesophageal peristalsis. The clinical, physiological, and radiological details of 27 patients with HLOS diagnosed in a 3-year period were reviewed. The reasons for referral included: gastro-oesophageal reflux disease (GORD) (33%), dysphagia (18.5%), epigastric discomfort (11%), non-cardiac chest pain (15%), globus (7.5%) and other (15%). All patients had manometric evidence of HLOS (Median LOS pressure 30 mmHg, range 25-50 mmHg) and 6 patients (20.7%) had abnormal pH studies. Less than 22% of contrast studies demonstrated an abnormality. There was no change in manometric findings following pharmacological treatment. Two patients underwent oesophagomyotomy and had normal manometry on follow up. We conclude that HLOS mimics a variety of upper gastrointestinal disorders and oesophageal manometry is the gold standard of diagnosis. There was an unexpectedly high incidence of GORD (22%) in this group. The significance and treatment of HLOS is discussed. |
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Authors:
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K J Sweeney; I Rowe; P Lawlor; P Byrne; J V Reynolds |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Irish medical journal Volume: 93 ISSN: 0332-3102 ISO Abbreviation: Ir Med J Publication Date: 2000 Nov |
Date Detail:
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Created Date: 2000-12-29 Completed Date: 2001-01-25 Revised Date: 2009-10-26 |
Medline Journal Info:
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Nlm Unique ID: 0430275 Medline TA: Ir Med J Country: Ireland |
Other Details:
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Languages: eng Pagination: 232-4 Citation Subset: IM |
Affiliation:
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Department of Clinical Surgery, St James's Hospital, Dublin. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Esophageal Motility Disorders / diagnosis, physiopathology*, therapy Esophagogastric Junction / physiopathology* Female Gastrointestinal Diseases / physiopathology* Humans Hydrogen-Ion Concentration Male Manometry Peristalsis Pressure |
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