Document Detail

The isochromosome (17q) in chronic myelocytic leukaemia: mechanism of origin, centromeric function and clonal evolution.
MedLine Citation:
PMID:  6961099     Owner:  NLM     Status:  MEDLINE    
An isochromosome (17q) may be observed in myelo- and lymphoproliferative disorders, as well as in solid tumours and it is very frequent in Ph1-positive chronic myelocytic leukaemia (CML) during the blastic phase. A study on the mechanism of origin and on the centromeric function of the i(17q)s was performed by means of the C- and Cd-staining techniques in four CML patients. In all these cases, as well as in four others reported in the literature, the i(17q) is dicentric thus indicating that its origin is due to a break on the short arms followed by joining of the two chromatids containing the centromere. The Cd-technique indicates that one of the two centromeres is inactive: this result is consistent with the fact that the i(17q) in CML is a step in the clonal evolution towards the acute phase.
F Pasquali; C Panarello; P Bernasconi; R Casalone
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Human genetics     Volume:  62     ISSN:  0340-6717     ISO Abbreviation:  Hum. Genet.     Publication Date:  1982  
Date Detail:
Created Date:  1983-03-17     Completed Date:  1983-03-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7613873     Medline TA:  Hum Genet     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  89-90     Citation Subset:  IM    
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MeSH Terms
Centromere / physiology
Chromosome Aberrations*
Chromosome Banding
Chromosomes, Human, 16-18 / ultrastructure*
Clone Cells
Leukemia, Myeloid / genetics*
Middle Aged

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