Document Detail

The αβδ of ion channels in human islet cells.
MedLine Citation:
PMID:  21099266     Owner:  NLM     Status:  MEDLINE    
Ion channels in the plasma membrane are critical for coupling metabolic signals to hormone release from pancreatic islet cells. The increased availability of human islets for research purposes has recently enabled us to perform a more detailed characterization of ion channels in human β-cells as well as in human δ- and α-cells. This addendum summarizes the major differences between mouse and human β-cells and discusses some of the remaining open questions. In addition, differences between the ion channel complements of human β-cells and islet non-β-cells are addressed.
Matthias Braun
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Publication Detail:
Type:  Comment; Comparative Study; Journal Article    
Journal Detail:
Title:  Islets     Volume:  1     ISSN:  1938-2022     ISO Abbreviation:  Islets     Publication Date:    2009 Sep-Oct
Date Detail:
Created Date:  2010-11-24     Completed Date:  2011-03-31     Revised Date:  2014-10-09    
Medline Journal Info:
Nlm Unique ID:  101495366     Medline TA:  Islets     Country:  United States    
Other Details:
Languages:  eng     Pagination:  160-2     Citation Subset:  IM    
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MeSH Terms
Calcium / metabolism
Glucose / metabolism,  pharmacology
Ion Channels / drug effects,  metabolism,  physiology*
Islets of Langerhans / cytology,  drug effects,  metabolism*,  physiology
Membrane Potentials / physiology
Models, Biological
Reg. No./Substance:
0/Ion Channels; IY9XDZ35W2/Glucose; SY7Q814VUP/Calcium
Comment On:
Diabetologia. 2009 Aug;52(8):1566-78   [PMID:  19440689 ]
Diabetes. 2008 Jun;57(6):1618-28   [PMID:  18390794 ]

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