Document Detail

T(14;18)(q32;q21) involving MALT1 and IGH genes in an extranodal diffuse large B-cell lymphoma.
MedLine Citation:
PMID:  14652825     Owner:  NLM     Status:  MEDLINE    
Two translocations involving the MALT1 gene have been described in extranodal marginal zone B-cell lymphomas of MALT type. A t(11;18)(q21;q21) involving API2 and MALT1 occurs in a subset of MALT lymphomas but with only rare exception is absent in diffuse large B-cell lymphomas (DLBCL), even at MALT sites. More recently, a t(14;18)(q32;q21) involving IGH and MALT1 has been described in nongastric extranodal MALT lymphomas. This translocation is indistinguishable from the IGH-BCL2 translocation by using classical cytogenetics. We report the IGH-MALT1 translocation in a cutaneous DLBCL as shown by classical cytogenetics and molecular cytogenetic analysis. This is the first report of an IGH-MALT1 translocation in DLBCL. These findings indicate that MALT1 translocations are not restricted to indolent-appearing lymphomas, provide further evidence that API2-MALT1 and IGH-MALT1 translocations exhibit biologic differences, have implications regarding the pathogenesis of some extranodal DLBCL, and emphasize that a t(14;18)(q32;q21) cannot be assumed to reflect a BCL2 translocation.
James R Cook; Maureen Sherer; Fiona E Craig; Sofia Shekhter-Levin; Steven H Swerdlow
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Human pathology     Volume:  34     ISSN:  0046-8177     ISO Abbreviation:  Hum. Pathol.     Publication Date:  2003 Nov 
Date Detail:
Created Date:  2003-12-03     Completed Date:  2004-01-21     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9421547     Medline TA:  Hum Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1212-5     Citation Subset:  IM    
Department of Pathology, University of Pittsburgh School of Medicine, PA 15213, USA.
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MeSH Terms
Chromosome Aberrations
Chromosomes, Human, Pair 14
Chromosomes, Human, Pair 18
Forearm / pathology
Genes, Immunoglobulin*
In Situ Hybridization, Fluorescence
Lymphoma, B-Cell / genetics*
Lymphoma, B-Cell, Marginal Zone / genetics*
Lymphoma, Large B-Cell, Diffuse / genetics*
Neoplasm Proteins / genetics*
Skin Neoplasms / genetics*
Translocation, Genetic
Reg. No./Substance:
0/Neoplasm Proteins; EC 3.4.22.-/Caspases; EC 3.4.22.-/MALT1 protein, human

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