Document Detail

The involvement of serum serotonin levels producing radiation-induced bystander effects for an in vivo assay with fractionated high dose-rate (HDR) brachytherapy.
MedLine Citation:
PMID:  22849323     Owner:  NLM     Status:  MEDLINE    
PURPOSE: The primary goal of this investigation was to observe whether measurable levels of bystander factor(s) can be detected in esophageal carcinoma patients' urine samples taken after undergoing high dose rate (HDR) intraluminal brachytherapy (ILBT). However, a small pilot study was developed to evaluate whether serotonin [5-Hydroxytryptamine (5-HT)] serum levels play an active role in the mechanisms of radiation-induced bystander effects (RIBE) at high doses.
MATERIALS AND METHODS: In the present study, a colony-forming in vivo assay was developed and used for the detection of non-targeted effects. Samples of urine were collected from five esophageal carcinoma patients undergoing fractionated HDR-ILBT. To observe whether 5-HT modulates the bystander effect at higher doses, different batches of foetal bovine serum (FBS) and 5-HT were tested on the same urine samples before and after brachytherapy.
RESULTS: Some of our data suggests statistically significant evidence for serotonin playing an active role as a signalling molecule at higher doses when patients underwent HDR-ILBT.
CONCLUSION: However, a more thorough investigation, with a larger sample size, is warranted before serotonin can be known to play a role in bystander effects at this particular dose range and treatment regime.
Christine Pinho; Raimond Wong; Ranjan K Sur; Joseph E Hayward; Thomas J Farrell; Colin Seymour; Carmel Mothersill
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of radiation biology     Volume:  88     ISSN:  1362-3095     ISO Abbreviation:  Int. J. Radiat. Biol.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-09-28     Completed Date:  2012-12-13     Revised Date:  2014-07-31    
Medline Journal Info:
Nlm Unique ID:  8809243     Medline TA:  Int J Radiat Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  791-7     Citation Subset:  IM; S    
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MeSH Terms
Bystander Effect / drug effects*,  radiation effects*
Cell Line
Cell Survival / drug effects,  radiation effects
Culture Media / chemistry*
Dose Fractionation*
Dose-Response Relationship, Drug
Esophageal Neoplasms / pathology,  radiotherapy,  urine
Serotonin / blood*,  pharmacology*
Reg. No./Substance:
0/Culture Media; 333DO1RDJY/Serotonin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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