Document Detail


The involvement of plasma kinins in the cardiovascular effects of Leiurus quinquestriatus scorpion venom in anaesthetised rabbits.
MedLine Citation:
PMID:  9637372     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The present study was undertaken to investigate the involvement of kinins in the cardiovascular- and respiratory effects of LQQ venom. Blood pressure, heart rate, electrocardiogram (ECG) and respiration were studied in anaesthetised rabbits, in the presence and absence of aprotinin and icatibant, a B2 bradykinin antagonist. Plasma bradykinin concentrations were also measured following venom injection. LQQ venom caused a triphasic effect on blood pressure comprising an immediate fall, a pronounced rise and a progressive decline until death. Bradycardia, myocardial damage, arrhythmias, respiratory distress and pulmonary oedema were also exhibited. Pretreatment with aprotinin attenuated the venom-induced hypotension, bradycardia, ECG and respiratory changes and prolonged survival. Pretreatment of atropinized animals with icatibant gave similar protection. In animals treated with LQQ venom, plasma bradykinin was significantly higher than controls, although there was considerable inter-animal variation in plasma kinin concentrations and the elevation was seen relatively late after venom administration. The data provides some support for the hypothesis that kinins are involved in the cardiovascular and lethal effects of LQQ venom in rabbits.
Authors:
A J Fatani; B L Furman; I J Zeitlin
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Toxicon : official journal of the International Society on Toxinology     Volume:  36     ISSN:  0041-0101     ISO Abbreviation:  Toxicon     Publication Date:  1998 Mar 
Date Detail:
Created Date:  1998-09-10     Completed Date:  1998-09-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1307333     Medline TA:  Toxicon     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  523-36     Citation Subset:  IM    
Affiliation:
Department of Physiology and Pharmacology, University of Strathclyde, Royal College, Glasgow, UK.
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MeSH Terms
Descriptor/Qualifier:
Adrenergic beta-Antagonists / administration & dosage,  pharmacology
Animals
Aprotinin / administration & dosage,  pharmacology
Blood Pressure / drug effects*
Bradykinin / administration & dosage,  analogs & derivatives,  blood,  pharmacology
Electrocardiography / drug effects
Heart Rate / drug effects*
Peptides / administration & dosage,  pharmacology
Rabbits
Receptors, Bradykinin / antagonists & inhibitors
Respiration / drug effects
Scorpion Venoms / administration & dosage,  pharmacology*
Serine Proteinase Inhibitors / pharmacology
Chemical
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 0/Peptides; 0/Receptors, Bradykinin; 0/Scorpion Venoms; 0/Serine Proteinase Inhibitors; 0/leiurutoxin III; 130308-48-4/icatibant; 58-82-2/Bradykinin; 9087-70-1/Aprotinin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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