| The involvement of o-antigen polysaccharide in lipopolysaccharide in macrophage activation. | |
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MedLine Citation:
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PMID: 22641671 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Bacterial lipopolysaccharide (LPS), which is generally considered to be an endotoxin, is the major constituent of the outer membrane of Gram-negative bacteria. The structure of LPS consists of three regions; lipid A, core oligosaccharide and O-antigen polysaccharide (O-PS). The structures of lipid A and core oligosaccharide are highly conserved among bacterial genera, but that of O-PS varies and differs in common bacterial species. Although studies of the biological activities of LPS have mainly focused on the lipid A moiety, a recent study gradually clarified the importance of O-PS to elicit the biological activities. In this review, we summarize previous studies on the correlation between the structure of O-PS and the biological activity of LPS, and discuss the possibility of innovative drug development using modified and synthetic LPS. |
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Authors:
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Misato Shimada; Takeshi Kadowaki; Yoshie Taniguchi; Hiroyuki Inagawa; Kathuichiro Okazaki; Gen-Ichiro Soma |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Anticancer research Volume: 32 ISSN: 1791-7530 ISO Abbreviation: Anticancer Res. Publication Date: 2012 Jun |
Date Detail:
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Created Date: 2012-05-29 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8102988 Medline TA: Anticancer Res Country: Greece |
Other Details:
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Languages: eng Pagination: 2337-41 Citation Subset: IM |
Affiliation:
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Institute for Health Science, Tokushima Bunri University, Nishihama, Yamashiro-cho, Tokushima-shi, 770-8514, Japan. sma5628@tokushima.bunri-u.ac.jp. |
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