Document Detail


The involvement of neuropeptide Y Y1 receptors in the blood pressure baroreflex: studies with BIBP 3226 and BIBO 3304.
MedLine Citation:
PMID:  10448884     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To ascertain the role of the neuropeptide Y Y1 receptors in the vascular manifestations of the sympathetic baroreflex, 10-s bilateral carotid occlusions were performed in anesthetized cats; systemic blood pressure was monitored continually. This maneuver rose systolic blood pressure in 23 +/- 2 mmHg. Following 100 microg/kg BIBP 3226 or BIBO 3304 i.v., the increase in blood pressure elicited by the occlusions was only 14 +/- 1 and 15 mmHg, respectively. Both BIBP 3226 and BIBO 3304 displaced significantly 5.5 fold rightward the pressor dose-response curve elicited by exogenous neuropeptide Y, without altering the norepinephrine curve. Prazosin (10 microg/kg) reduced the pressor response elicited by the carotid occlusion to 12 +/- 4 mmHg. The simultaneous administration of BIBP 3226 plus prazosin rose the systemic blood pressure following the occlusion only 9 +/- 2 mmHg, supporting the involvement of neuropeptide Y in vascular sympathetic reflexes.
Authors:
D Capurro; J P Huidobro-Toro
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of pharmacology     Volume:  376     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  1999 Jul 
Date Detail:
Created Date:  1999-09-22     Completed Date:  1999-09-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  251-5     Citation Subset:  IM    
Affiliation:
Department of Physiology, Faculty of Biological Sciences, P. Catholic University of Chile, Santiago.
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MeSH Terms
Descriptor/Qualifier:
Animals
Arginine / analogs & derivatives*,  pharmacology
Baroreflex / drug effects*,  physiology
Blood Pressure / drug effects*,  physiology
Cardiovascular Agents / pharmacology*
Carotid Arteries / drug effects
Cats
Dose-Response Relationship, Drug
Ligation
Neuropeptide Y / pharmacology*
Receptors, Neuropeptide Y / antagonists & inhibitors*,  physiology
Chemical
Reg. No./Substance:
0/BIBO 3304; 0/BIBP 3226; 0/Cardiovascular Agents; 0/Neuropeptide Y; 0/Receptors, Neuropeptide Y; 0/neuropeptide Y-Y1 receptor; 74-79-3/Arginine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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