| The involvement of circulating microparticles in inflammation, coagulation and cardiovascular diseases. | |
| | |
MedLine Citation:
|
PMID: 20386775 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Microparticles (MPs) are small vesicles, ranging in size from 0.1 microm to 2 microm, originating from plasma membranes of endothelial cells, platelets, leukocytes and erythrocytes. MPs can transfer antigens and receptors to cell types that are different from their cell of origin. Circulating MPs provide a procoagulant aminophospholipid surface for the assembly of the specific enzymes of coagulation. Both tissue factor and phosphatidylserine are exposed on MP outer membranes. In addition, MPs can play a significant role in vascular function and inflammation by modulating nitric oxide and prostacyclin production in endothelial cells, and stimulating cytokine release and tissue factor induction in endothelial cells, as well as monocyte chemotaxis and adherence to the endothelium. Finally, increased levels of MPs have been found in the presence of acute coronary syndromes, ischemic stroke, diabetes, systemic and pulmonary hypertension, and hypertriglyceridemia. From a practical point of view, MPs could be considered to be important markers of cardiovascular risk, as well as surrogate end points for assessing the efficacy of new drugs and therapies. |
| | |
Authors:
|
Paolo Puddu; Giovanni M Puddu; Eleonora Cravero; Silvia Muscari; Antonio Muscari |
Related Documents
:
|
15678705 - The role of the infectious agents in the pathogenesis and evolution of atherosclerosis. 2827655 - Regulation of angiotensin converting enzyme activity in cultured human vascular endothe... 19164065 - A non-invasive assessment for endothelial function of small animals. 16875715 - Endothelial cell infection and hemostasis. 18451535 - Inhibition of angiogenesis by a tenascin-c peptide which is capable of activating beta1... 22506045 - Circulating angiogenic factors in patients with thromboangiitis obliterans. |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: The Canadian journal of cardiology Volume: 26 ISSN: 1916-7075 ISO Abbreviation: Can J Cardiol Publication Date: 2010 Apr |
Date Detail:
|
Created Date: 2010-04-13 Completed Date: 2010-05-04 Revised Date: 2011-07-27 |
Medline Journal Info:
|
Nlm Unique ID: 8510280 Medline TA: Can J Cardiol Country: Canada |
Other Details:
|
Languages: eng Pagination: 140-5 Citation Subset: IM |
Affiliation:
|
Department of Internal Medicine, University of Bologna and S Orsola-Malpighi Hospital, Italy. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Blood Coagulation
/
physiology* Blood Platelets / physiology* Cardiovascular Diseases / blood Cell Membrane / physiology Cell-Derived Microparticles / physiology* Endothelium, Vascular / physiology Humans Inflammation / blood* Platelet Aggregation / physiology Platelet Aggregation Inhibitors / therapeutic use |
| Chemical | |
Reg. No./Substance:
|
0/Platelet Aggregation Inhibitors |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The prevalence and clinical impact of obesity in adults with Marfan syndrome.
Next Document: The first case of takotsubo cardiomyopathy associated with sodium tetradecyl sulphate sclerotherapy.