Document Detail


The involvement of circulating microparticles in inflammation, coagulation and cardiovascular diseases.
MedLine Citation:
PMID:  20386775     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Microparticles (MPs) are small vesicles, ranging in size from 0.1 microm to 2 microm, originating from plasma membranes of endothelial cells, platelets, leukocytes and erythrocytes. MPs can transfer antigens and receptors to cell types that are different from their cell of origin. Circulating MPs provide a procoagulant aminophospholipid surface for the assembly of the specific enzymes of coagulation. Both tissue factor and phosphatidylserine are exposed on MP outer membranes. In addition, MPs can play a significant role in vascular function and inflammation by modulating nitric oxide and prostacyclin production in endothelial cells, and stimulating cytokine release and tissue factor induction in endothelial cells, as well as monocyte chemotaxis and adherence to the endothelium. Finally, increased levels of MPs have been found in the presence of acute coronary syndromes, ischemic stroke, diabetes, systemic and pulmonary hypertension, and hypertriglyceridemia. From a practical point of view, MPs could be considered to be important markers of cardiovascular risk, as well as surrogate end points for assessing the efficacy of new drugs and therapies.
Authors:
Paolo Puddu; Giovanni M Puddu; Eleonora Cravero; Silvia Muscari; Antonio Muscari
Related Documents :
15678705 - The role of the infectious agents in the pathogenesis and evolution of atherosclerosis.
2827655 - Regulation of angiotensin converting enzyme activity in cultured human vascular endothe...
19164065 - A non-invasive assessment for endothelial function of small animals.
16875715 - Endothelial cell infection and hemostasis.
18451535 - Inhibition of angiogenesis by a tenascin-c peptide which is capable of activating beta1...
22506045 - Circulating angiogenic factors in patients with thromboangiitis obliterans.
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The Canadian journal of cardiology     Volume:  26     ISSN:  1916-7075     ISO Abbreviation:  Can J Cardiol     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-04-13     Completed Date:  2010-05-04     Revised Date:  2011-07-27    
Medline Journal Info:
Nlm Unique ID:  8510280     Medline TA:  Can J Cardiol     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  140-5     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine, University of Bologna and S Orsola-Malpighi Hospital, Italy.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Blood Coagulation / physiology*
Blood Platelets / physiology*
Cardiovascular Diseases / blood
Cell Membrane / physiology
Cell-Derived Microparticles / physiology*
Endothelium, Vascular / physiology
Humans
Inflammation / blood*
Platelet Aggregation / physiology
Platelet Aggregation Inhibitors / therapeutic use
Chemical
Reg. No./Substance:
0/Platelet Aggregation Inhibitors
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The prevalence and clinical impact of obesity in adults with Marfan syndrome.
Next Document:  The first case of takotsubo cardiomyopathy associated with sodium tetradecyl sulphate sclerotherapy.