Document Detail

The involvement of circulating microparticles in inflammation, coagulation and cardiovascular diseases.
MedLine Citation:
PMID:  20386775     Owner:  NLM     Status:  MEDLINE    
Microparticles (MPs) are small vesicles, ranging in size from 0.1 microm to 2 microm, originating from plasma membranes of endothelial cells, platelets, leukocytes and erythrocytes. MPs can transfer antigens and receptors to cell types that are different from their cell of origin. Circulating MPs provide a procoagulant aminophospholipid surface for the assembly of the specific enzymes of coagulation. Both tissue factor and phosphatidylserine are exposed on MP outer membranes. In addition, MPs can play a significant role in vascular function and inflammation by modulating nitric oxide and prostacyclin production in endothelial cells, and stimulating cytokine release and tissue factor induction in endothelial cells, as well as monocyte chemotaxis and adherence to the endothelium. Finally, increased levels of MPs have been found in the presence of acute coronary syndromes, ischemic stroke, diabetes, systemic and pulmonary hypertension, and hypertriglyceridemia. From a practical point of view, MPs could be considered to be important markers of cardiovascular risk, as well as surrogate end points for assessing the efficacy of new drugs and therapies.
Paolo Puddu; Giovanni M Puddu; Eleonora Cravero; Silvia Muscari; Antonio Muscari
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The Canadian journal of cardiology     Volume:  26     ISSN:  1916-7075     ISO Abbreviation:  Can J Cardiol     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-04-13     Completed Date:  2010-05-04     Revised Date:  2011-07-27    
Medline Journal Info:
Nlm Unique ID:  8510280     Medline TA:  Can J Cardiol     Country:  Canada    
Other Details:
Languages:  eng     Pagination:  140-5     Citation Subset:  IM    
Department of Internal Medicine, University of Bologna and S Orsola-Malpighi Hospital, Italy.
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MeSH Terms
Blood Coagulation / physiology*
Blood Platelets / physiology*
Cardiovascular Diseases / blood
Cell Membrane / physiology
Cell-Derived Microparticles / physiology*
Endothelium, Vascular / physiology
Inflammation / blood*
Platelet Aggregation / physiology
Platelet Aggregation Inhibitors / therapeutic use
Reg. No./Substance:
0/Platelet Aggregation Inhibitors

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