| The involvement of brain serotonin in excessive carbohydrate snacking by obese carbohydrate cravers. | |
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MedLine Citation:
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PMID: 6381575 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A specific hunger for carbohydrate-rich foods has been observed in animals and human beings and appears to be regulated by the brain neurotransmitter serotonin. Consumption of a carbohydrate-rich meal increases the synthesis and release of brain serotonin (by enhancing the brain uptake of its precursor, tryptophan). As a consequence of this increased release of serotonin, carbohydrate intake is decreased at the next meal. Consumption of protein does not increase brain serotonin levels or decrease carbohydrate intake. A subgroup of obese individuals who consume carbohydrate-rich snack foods at specific times of day or evening has been identified. Such individuals do not routinely snack on protein-rich foods, and their consumption of calories and nutrients at meals is not excessive. Evidence is presented that carbohydrate snacking seems to be related to a "need" to increase the level of brain serotonin; treatment with a drug, d-1 fenfluramine, that increases serotoninergic neurotransmission significantly decreases carbohydrate snack consumption. Weight loss among the population of carbohydrate cravers might be most successful if treatment includes either a diet or drugs that increase brain serotonin activity when the need to snack on carbohydrate is most likely to occur. |
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Authors:
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J J Wurtman |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Journal of the American Dietetic Association Volume: 84 ISSN: 0002-8223 ISO Abbreviation: J Am Diet Assoc Publication Date: 1984 Sep |
Date Detail:
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Created Date: 1984-10-18 Completed Date: 1984-10-18 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7503061 Medline TA: J Am Diet Assoc Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1004-7 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Animals Brain / drug effects*, metabolism Dietary Carbohydrates / pharmacology* Dietary Proteins Fenfluramine / pharmacology*, therapeutic use Food Preferences / drug effects Humans Obesity / diet therapy, drug therapy Serotonin / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Dietary Carbohydrates; 0/Dietary Proteins; 458-24-2/Fenfluramine; 50-67-9/Serotonin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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