| The involvement of Kupffer cells and liver endothelial cells in the clearance of large sized soluble IgA aggregates in rats. | |
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MedLine Citation:
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PMID: 7502751 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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These findings suggests that AIgA is bound both by KC and EC in normal situations. Because of the great phagocytic capacity of KC, the contribution of EC in handling AIgA in normal rats is minimal. However, when KC are defect or absent (as after Cl2MDP treatment), the handling of AIgA by EC may become of mayor importance, i.e. it will take over the phagocytic function of KC. Studies concerning a possible receptor on EC involved in binding of AIgA are in progress. |
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Authors:
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R K Stad; W M Bogers; L A van Es; M R Daha |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Advances in experimental medicine and biology Volume: 371B ISSN: 0065-2598 ISO Abbreviation: Adv. Exp. Med. Biol. Publication Date: 1995 |
Date Detail:
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Created Date: 1996-01-16 Completed Date: 1996-01-16 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0121103 Medline TA: Adv Exp Med Biol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1053-5 Citation Subset: IM |
Affiliation:
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Department of Nephrology, University Hospital Leiden, The Netherlands. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biopolymers / blood, chemistry, metabolism* Complement System Proteins / metabolism Endothelium / cytology, immunology Immunoglobulin A / blood, chemistry, metabolism* Kinetics Kupffer Cells / immunology* Liver / cytology, immunology* Rats Solubility |
| Chemical | |
Reg. No./Substance:
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0/Biopolymers; 0/Immunoglobulin A; 0/polymeric IgA; 9007-36-7/Complement System Proteins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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