Document Detail


The involvement of HLA -DRB1*, DQA1*, DQB1* and complement C4A loci in diagnosing systemic lupus erythematosus among Tunisians.
MedLine Citation:
PMID:  15310011     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Genetic susceptibility to systemic lupus erythematosus (SLE) varies among populations. Few data exist on associations of HLA class II and class III alleles of the major histocompatibility complex (MHC) and susceptibility to SLE in Tunisians. PATIENTS AND METHODS: We compared HLA-DRB1*, DQA1, DQB1* and C4 allotypes in 62 Tunisian SLE patients and 100 matched controls. We also assessed the association of specific alleles with distinct autoantibody profiles in SLE patients. RESULTS: HLA-DRB1*0301, -DRB1*1501 and C4AQO alleles were increased in the SLE patients, while the frequencies of HLA-DRB1*04 and DQB1*03 were decreased. HLA-DQA1*0102 and DQA1*0501 were significantly increased in the SLE patients. HLA-DQB1*0201 and DQB1*0602 were more frequent in the SLE patients. C4A*QO and C4B*QO were increased in frequency in the SLE patients compared to the controls, but only C4A null was significantly increased. Eleven of 17 SLE patients with the C4 null allele were HLA-DRB1*0301 positive. Three of 16 SLE patients with HLA-DRB1*1501 were associated with HLA-DQB1*0501 rather than DQB1*0602, as has been reported in European SLE patients. CONCLUSIONS: The MHC class II alleles (DRB1, DQA1, DQB1) and C4 null associations noted in other ethnic groups are also found in Tunisians, suggesting shared susceptibility factors across ethnic lines in predisposition to SLE. In contrast to other ethnic groups, MHC class II alleles are not associated with the presence of specific autoantibodies in Tunisian SLE patients.
Authors:
Khaled Ayed; Yousr Gorgi; Saloua Ayed-Jendoubi; Rafika Bardi
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Annals of Saudi medicine     Volume:  24     ISSN:  0256-4947     ISO Abbreviation:  Ann Saudi Med     Publication Date:    2004 Jan-Feb
Date Detail:
Created Date:  2004-08-16     Completed Date:  2004-11-04     Revised Date:  2010-10-15    
Medline Journal Info:
Nlm Unique ID:  8507355     Medline TA:  Ann Saudi Med     Country:  Saudi Arabia    
Other Details:
Languages:  eng     Pagination:  31-5     Citation Subset:  IM    
Affiliation:
Department of Immunology, Faculty of Medicine and Laboratory of Immunology, Charles Nicolle Hospital, Tunis, Tunisia. khaled.ayed@rns.tn
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MeSH Terms
Descriptor/Qualifier:
Case-Control Studies
Complement C4a / analysis*
Female
HLA-DQ Antigens / blood*
HLA-DR Antigens / blood*
Humans
Immunoglobulin Allotypes
Lupus Erythematosus, Systemic / blood,  diagnosis*,  epidemiology,  immunology*
Male
Phenotype
Reference Values
Tunisia / epidemiology
Chemical
Reg. No./Substance:
0/HLA-DQ Antigens; 0/HLA-DQA1; 0/HLA-DQB1 antigen; 0/HLA-DR Antigens; 0/Immunoglobulin Allotypes; 128338-86-3/HLA-DRB1 antigen; 80295-49-4/Complement C4a

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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