| An investigation to show the effect of lung fluid on impedance cardiac output in the anaesthetized dog. | |
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MedLine Citation:
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PMID: 16051651 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Accumulation of lung fluid in the critically ill patient is believed to attenuate impedance cardiac output (CO(IC)) measurements. However, this phenomenon has never been shown experimentally. METHODS: In eight anaesthetized and ventilated dogs (weight 15-22 kg) a high-precision flow probe was placed on the ascending aorta via a left thoracotomy incision and the direct cardiac output (CO(FP)) was measured. Simultaneous CO(IC) measurements were made using a RheoCardioMonitor (ACMA, Singapore). Lung oedema was induced by intravenous oleic acid 0.1 mg kg(-1). Lung fluid was assessed by the decrease in basal thoracic impedance (Z(b)). Percentage errors between the two methods (CO(IC)-CO(FP)) were calculated and compared as Z(b) decreased at 1 Omega intervals. RESULTS: During the experiment mean Z(b) decreased from 35.9 (sd 5.2) to 27.8 (6.5) Omega (P=0.0037). This occurred over a period of 225 (range 112-338) min and Z(b) decreased by 1 Omega every 51 (22-68) min. The presence of excessive lung fluid was confirmed at post-mortem. Before lung oedema was induced, CO(IC) was 1.5 (0.6) litre min(-1) and the corresponding value of CO(FP) was 1.5 (0.7) litre min(-1) (data from eight dogs). As Z(b) decreased, and lung fluid accumulated, the error between CO(IC) and CO(FP) widened (P<0.0001, anova for repeated measures). Eventually, CO(IC) decreased to 0.7 (0.3) litre min(-1) and the corresponding value of CO(FP) was 1.2 (0.3) litre min(-1) (DeltaZ(b)=5 Omega, data from six dogs). Mean arterial pressure, central venous pressure and systemic vascular resistance were kept constant. CONCLUSION: The presence of lung fluid attenuates CO(IC) measurements with respect to CO(FP). |
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Authors:
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Z-Y Peng; L A H Critchley; B S P Fok |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2005-07-28 |
Journal Detail:
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Title: British journal of anaesthesia Volume: 95 ISSN: 0007-0912 ISO Abbreviation: Br J Anaesth Publication Date: 2005 Oct |
Date Detail:
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Created Date: 2005-09-12 Completed Date: 2005-11-15 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372541 Medline TA: Br J Anaesth Country: England |
Other Details:
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Languages: eng Pagination: 458-64 Citation Subset: IM |
Affiliation:
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Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Shatin. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Aorta / physiopathology Cardiac Output* Cardiography, Impedance Dogs Hemodynamics Male Monitoring, Physiologic / methods Oleic Acid Pulmonary Edema / chemically induced, physiopathology* Reproducibility of Results |
| Chemical | |
Reg. No./Substance:
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112-80-1/Oleic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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