Document Detail


An investigation of risk factors for renal cell carcinoma by histologic subtype in two case-control studies.
MedLine Citation:
PMID:  23150424     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To investigate whether renal cell carcinoma (RCC) histologic subtypes possess different etiologies, we conducted analyses of established RCC risk factors by subtype (clear cell, papillary and chromophobe) in two case-control studies conducted in the United States (1,217 cases, 1,235 controls) and Europe (1,097 cases, 1,476 controls). Histology was ascertained for 706 U.S. cases (58% of total) and 917 European cases (84%) through a central slide review conducted by a single pathologist. For the remaining cases, histology was abstracted from the original diagnostic pathology report. Case-only analyses were performed to compute odds ratios (ORs) and 95% confidence intervals (CI) summarizing subtype differences by age, sex and race. Case-control analyses were performed to compute subtype-specific ORs for other risk factors using polytomous regression. In case-only analyses, papillary cases (N = 237) were older (OR = 1.2, 95% CI = 1.1-1.4 per 10-year increase), less likely to be female (OR = 0.5, 95% CI = 0.4-0.8) and more likely to be black (OR = 2.6, 95% CI = 1.8-3.9) as compared to clear cell cases (N = 1,524). In case-control analyses, BMI was associated with clear cell (OR = 1.2, 95% CI = 1.1-1.3 per 5 kg/m(2) increase) and chromophobe RCC (N = 80; OR = 1.2, 95% CI = 1.1-1.4), but not papillary RCC (OR = 1.1, 95% CI = 1.0-1.2; test versus clear cell, p = 0.006). No subtype differences were observed for associations with smoking, hypertension or family history of kidney cancer. Our findings support the existence of distinct age, sex and racial distributions for RCC subtypes, and suggest that the obesity-RCC association differs by histology.
Authors:
Mark P Purdue; Lee E Moore; Maria J Merino; Paolo Boffetta; Joanne S Colt; Kendra L Schwartz; Vladimir Bencko; Faith G Davis; Barry I Graubard; Vladimir Janout; Julie J Ruterbusch; Jennifer Beebe-Dimmer; Michele L Cote; Brian Shuch; Dana Mates; Jonathan N Hofmann; Lenka Foretova; Nathaniel Rothman; Neonilia Szeszenia-Dabrowska; Vsevolod Matveev; Sholom Wacholder; David Zaridze; W Marston Linehan; Paul Brennan; Wong-Ho Chow
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Publication Detail:
Type:  Comparative Study; Journal Article; Multicenter Study; Research Support, N.I.H., Intramural     Date:  2013-01-15
Journal Detail:
Title:  International journal of cancer. Journal international du cancer     Volume:  132     ISSN:  1097-0215     ISO Abbreviation:  Int. J. Cancer     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-03-26     Completed Date:  2013-05-28     Revised Date:  2014-06-03    
Medline Journal Info:
Nlm Unique ID:  0042124     Medline TA:  Int J Cancer     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2640-7     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 UICC.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Carcinoma, Renal Cell / epidemiology,  etiology*
Case-Control Studies
Europe / epidemiology
Female
Follow-Up Studies
Humans
Kidney Neoplasms / epidemiology,  etiology*
Male
Middle Aged
Obesity / complications*
Prognosis
United States / epidemiology
Young Adult
Grant Support
ID/Acronym/Agency:
P30 CA022453/CA/NCI NIH HHS; ZIA CP010123-15/CP/NCI NIH HHS
Comments/Corrections
Comment In:
J Urol. 2014 Jan;191(1):55   [PMID:  24331471 ]

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