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An investigation of the relationship between hemodynamics and thrombus deposition within patient-specific models of abdominal aortic aneurysm.
MedLine Citation:
PMID:  22913102     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
The relationship between hemodynamics and thrombus deposition in abdominal aortic aneurysm is investigated for three patients (A, B and C), each with mature fusiform aneurysms. Our methodology utilises initial and follow-up computerised tomography scans for each patient to identify regions of mural thrombus growth and to provide patient-specific models for hemodynamic analysis using computational fluid dynamics. The intervals between scans for patients A, B and C were 17, 15 and 3 months, respectively. The simulations were performed using physiologically realistic boundary conditions. The hemodynamic features of the flow considered include the velocity field, the shear strain rate field, the time averaged wall shear stress and the oscillatory shear index. The parameter that showed best correlation with the location of thrombus growth was the oscillatory shear index. In particular, in the case of patient C where the interval between scans was the shortest, thrombus growth was observed at regions of low oscillatory shear index (OSI < 0.1).
Authors:
Malachy J O'Rourke; James P McCullough; Sinead Kelly
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Proceedings of the Institution of Mechanical Engineers. Part H, Journal of engineering in medicine     Volume:  226     ISSN:  0954-4119     ISO Abbreviation:  Proc Inst Mech Eng H     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-08-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8908934     Medline TA:  Proc Inst Mech Eng H     Country:  England    
Other Details:
Languages:  eng     Pagination:  548-64     Citation Subset:  IM    
Affiliation:
School of Mechanical and Materials Engineering, University College Dublin Engineering and Materials Science Centre, Dublin, Ireland. malachy.orourke@ucd.ie
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