| An investigation of the relationship between cortical connectivity and schizotypy in the general population. | |
| | |
MedLine Citation:
|
PMID: 21543955 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Recent neuroimaging investigations have identified a relationship between psychotic symptoms in schizophrenia and abnormal brain connectivity. On the basis of the continuum model of psychosis, it was hypothesized that schizotypal traits in healthy control participants would be associated with relatively impaired frontotemporal white matter health as assessed using diffusion tensor imaging. Twenty-one participants (12 women and 9 men aged 18 to 58 years) completed the Schizotypal Personality Questionnaire (SPQ) and underwent diffusion-weighted magnetic resonance imaging scanning as part of a larger study. White matter integrity for the major association fibre tracts was assessed using standard measures of diffusivity, specifically fractional anisotropy (FA) and axial and radial diffusivity. A series of negative binomial regressions yielded significant relationships between reduced FA in seven white matter tracts and increased scores on the SPQ cognitive-perceptual factor. These findings are consistent with research relating brain connectivity to the positive symptoms of schizophrenia, suggesting that the neurobiological bases of schizotypal personality in healthy controls may be analogous to the neurobiological bases of schizophrenia spectrum disorders. |
| | |
Authors:
|
Margaret T Nelson; Marc L Seal; Lisa J Phillips; Antonia H Merritt; Rebecca Wilson; Christos Pantelis |
Related Documents
:
|
21293025 - Intracortical infarcts in small vessel disease: a combined 7-t postmortem mri and neuro... 18690375 - Preoperative localization of parathyroid lesions. value of 99mtc-mibi tomography and fa... 10931075 - Management of the nontoxic multinodular goitre: a european questionnaire study. 19912075 - Magnetic resonance sialography using ciss and haste sequences in inflammatory salivary ... 20842185 - Imaging in the surgical treatment of epilepsy. 21293025 - Intracortical infarcts in small vessel disease: a combined 7-t postmortem mri and neuro... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: The Journal of nervous and mental disease Volume: 199 ISSN: 1539-736X ISO Abbreviation: J. Nerv. Ment. Dis. Publication Date: 2011 May |
Date Detail:
|
Created Date: 2011-05-05 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0375402 Medline TA: J Nerv Ment Dis Country: United States |
Other Details:
|
Languages: eng Pagination: 348-53 Citation Subset: AIM; IM |
Affiliation:
|
*Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health; †Psychological Sciences, The University of Melbourne; ‡Murdoch Childrens Research Institute, The Royal Children's Hospital, Parkville, Victoria; and §Schizophrenia Research Institute, Darlinghurst, New South Wales, Australia. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Threat/Control-override symptoms and emotional reactions to positive symptoms as correlates of aggre...
Next Document: Evaluating psychological insight in a clinical sample using the shedler-westen assessment procedure.