| An investigation of phenolic compounds from plant sources as trypsin inhibitors. | |
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MedLine Citation:
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PMID: 22011193 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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In the search of new trypsin inhibitors caffeic acid (1), cinnamic acid (2), gallic acid (3) and eugenol (4) from Cinnamomum zeylanicum, ferulic acid (5) from Impatiens bicolor, vanillin (6) from Melia azedarach and catechol (7) from Allium cepa were isolated through bioassay guided fractionation of the plant extracts. IC (50) values of the compounds 1, 2 and 5 were found to be 0.35 ± 0.02 mM, 0.96 ± 0.05 mM and 1.22 ± 0.06 mM, respectively. Lineweaver-Burk and Dixon plots and their secondary replots showed that 1 was non-competitive inhibitor of this enzyme with K(i) value 0.102 ± 0.006 mM. |
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Authors:
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Durre Shahwar; Muhammad Asam Raza; Shafiq-Ur-Rehman; Muhammad Athar Abbasi; Atta-Ur-Rahman |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-10-20 |
Journal Detail:
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Title: Natural product research Volume: - ISSN: 1478-6427 ISO Abbreviation: - Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-10-20 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101167924 Medline TA: Nat Prod Res Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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a Center for Natural Product Drug Development, Department of Chemistry , Government College University , Lahore , Pakistan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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