Document Detail

An investigation of phenolic compounds from plant sources as trypsin inhibitors.
MedLine Citation:
PMID:  22011193     Owner:  NLM     Status:  Publisher    
In the search of new trypsin inhibitors caffeic acid (1), cinnamic acid (2), gallic acid (3) and eugenol (4) from Cinnamomum zeylanicum, ferulic acid (5) from Impatiens bicolor, vanillin (6) from Melia azedarach and catechol (7) from Allium cepa were isolated through bioassay guided fractionation of the plant extracts. IC (50) values of the compounds 1, 2 and 5 were found to be 0.35 ± 0.02 mM, 0.96 ± 0.05 mM and 1.22 ± 0.06 mM, respectively. Lineweaver-Burk and Dixon plots and their secondary replots showed that 1 was non-competitive inhibitor of this enzyme with K(i) value 0.102 ± 0.006 mM.
Durre Shahwar; Muhammad Asam Raza; Shafiq-Ur-Rehman; Muhammad Athar Abbasi; Atta-Ur-Rahman
Related Documents :
11122713 - Dietary fatty acids and insulin resistance.
9694903 - Oleate potentiates oxysterol inhibition of transcription from sterol regulatory element...
3417823 - Determination of trichloroethylene metabolites in rat liver homogenate using headspace ...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-10-20
Journal Detail:
Title:  Natural product research     Volume:  -     ISSN:  1478-6427     ISO Abbreviation:  -     Publication Date:  2011 Oct 
Date Detail:
Created Date:  2011-10-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101167924     Medline TA:  Nat Prod Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
a Center for Natural Product Drug Development, Department of Chemistry , Government College University , Lahore , Pakistan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Electrochemical and structural properties of a protein system designed to generate tyrosine Pourbaix...
Next Document:  Case of muscle abscess due to disseminated nocardiosis in a patient with autoimmune hemolytic anemia...