Document Detail

An investigation into the susceptibility of cattle to bovine leukosis virus following inoculation by various routes.
MedLine Citation:
PMID:  6281957     Owner:  NLM     Status:  MEDLINE    
The effect of different routes of inoculation on the incubation period, as indicated by the detection of antibody and by the detection of bovine leukosis virus (BLV) in lymphocytes, were compared. None of the 12-month-old steers exposed to BLV by the oral route developed BLV infection. Intratracheal, subcutaneous and intradermal inoculations were found to be particularly effective in establishing BLV infection, which was detected three to four weeks after inoculation. In the majority of animals, serum antibody and virus were detected at the same time. One out of four in-oestrus heifers inoculated via the uterus with mixtures of BLV infected lymphocytes and semen became infected. It appears that there is an inhibitory factor in fresh semen that prevents BLV infection from becoming established. Viral antigen was detected earlier in BLV infected lymphocytes using the cocultivation method than by electron microscopy to demonstrate BLV particles in mitogen stimulated lymphocytes.
D H Roberts; M H Lucas; G Wibberley; D Chasey
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Veterinary record     Volume:  110     ISSN:  0042-4900     ISO Abbreviation:  Vet. Rec.     Publication Date:  1982 Mar 
Date Detail:
Created Date:  1982-07-08     Completed Date:  1982-07-08     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0031164     Medline TA:  Vet Rec     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  222-4     Citation Subset:  IM    
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MeSH Terms
Antibodies, Viral / analysis
Cattle Diseases / transmission*
Concanavalin A / pharmacology
Leukemia Virus, Bovine / immunology,  isolation & purification,  pathogenicity*
Lipopolysaccharides / pharmacology
Lymphocytes / drug effects,  immunology,  microbiology
Retroviridae / pathogenicity*
Sheep Diseases / transmission
Reg. No./Substance:
0/Antibodies, Viral; 0/Lipopolysaccharides; 11028-71-0/Concanavalin A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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