| An investigation of ethnic differences in bone mineral, hip axis length, calcium metabolism and bone turnover between West African and Caucasian adults living in the United Kingdom. | |
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MedLine Citation:
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PMID: 10355494 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of the study was to investigate factors relating to calcium and bone metabolism which might explain the low incidence of osteoporotic fracture among Africans. Adult bone mineral status, hip axis length and biochemical indices were investigated in 20 Caucasians (10 male, 10 female) and 19 Gambians (12 male, 7 female) living in the UK. Bone mineral content (BMC), bone mineral density (BMD) and BMC adjusted for bone area, body weight and height (size-adjusted BMC) were measured for the whole-body, lumbar spine, femoral neck, trochanter, radius shaft and radius wrist using dual-energy X-ray absorptiometry. There were no significant differences in whole body or regional BMC; values tended to be lower in the Gambians. Gambian men had higher size-adjusted BMC at the femoral neck (Gambian-British = 21%, 95% CI = 6 to 36%, p < 0.01), associated with a smaller bone area (Gambian-British = -11%, 95% CI = -20 to -2%, p = 0.02). BMD was affected similarly. No other significant differences in BMD or size-adjusted BMC were observed. Gambians had shorter hip axis length (Gambian British, after accounting for sex, = -5%, 95% CI = -9 to -1%, p = 0.02). There were no significant differences in bone turnover (osteocalcin, bone isoenzyme of alkaline phosphatase, urinary deoxypyridinoline) or calciotropic hormone levels (parathyroid hormone, 1,25-dihydroxyvitamin D, calcitonin). Gambian men had lower 25-hydroxyvitamin D concentrations (Gambian = 26.3 SD 12.0 nmol/L, British = 55.5 SD 13.9 nmol/L, p < 0.0001), a difference not seen among the women. Gambian men and women excreted significantly less phosphate and potassium than British subjects by 30-60%; urinary calcium and sodium excretion were similar in the two groups. This study revealed few ethnic differences that could account for the disparity in osteoporotic fracture rates between Africans and Caucasians, with the possible exception of anatomical differences in the hip. |
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Authors:
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B Dibba; A Prentice; M A Laskey; D M Stirling; T J Cole |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Annals of human biology Volume: 26 ISSN: 0301-4460 ISO Abbreviation: Ann. Hum. Biol. Publication Date: 1999 May-Jun |
Date Detail:
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Created Date: 1999-07-02 Completed Date: 1999-07-02 Revised Date: 2013-04-29 |
Medline Journal Info:
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Nlm Unique ID: 0404024 Medline TA: Ann Hum Biol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 229-42 Citation Subset: IM |
Affiliation:
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Medical Research Council Dunn Nutrition Unit, Cambridge, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Absorptiometry, Photon Adolescent Adult African Continental Ancestry Group* Body Height Body Weight Bone Density* Bone and Bones / chemistry, metabolism* Calcium / metabolism* Dihydroxycholecalciferols / analysis Ethnic Groups* European Continental Ancestry Group* Female Femur / anatomy & histology, chemistry Femur Neck / anatomy & histology, chemistry Fractures, Bone / etiology Gambia / ethnology Great Britain Hip Joint / anatomy & histology* Humans Lumbar Vertebrae / anatomy & histology, chemistry Male Middle Aged Osteoporosis / complications, metabolism Phosphates / urine Potassium / urine Radius / anatomy & histology, chemistry Sex Factors |
| Grant Support | |
ID/Acronym/Agency:
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G9827821//Medical Research Council; G9827821(62595)//Medical Research Council |
| Chemical | |
Reg. No./Substance:
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0/Dihydroxycholecalciferols; 0/Phosphates; 7440-09-7/Potassium; 7440-70-2/Calcium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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