| An investigation of clozapine in the treatment of acute and chronic schizophrenia and gross behaviour disorders. | |
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MedLine Citation:
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PMID: 1209429 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Fifty-two mental hospital cases of acute and chronic schizophrenia and gross behaviour disorders were investigated and observed for 6-12 months during treatment with clozapine. Three-quarters of the acute cases recovered with full occupation capacity. Two-thirds of the chronic cases improved markedly. Antisocial behaviour was controlled in 12 out of the 13 behaviour-disordered group. The improvement in initiative and social capacity was striking and appeared to be due to improved awareness of the environment and the acquisition and handling of useful knowledge. The response to clozapine appears to be specific and relapses occurred when maintenance medication was stopped. It is of value in treating temper states in epilepsy and has the advantage of not causing extrapyramidal symptoms and side-effects are slight after the first week. Maximum improvement may not be reached before 8 weeks. Thereafter the maintenance dose can be small and fluctuations in the illness do not seem to occur. The dosage, side-effects and precautions are discussed. A rating system to display the effect of clozapine on individual parameters as well as on the over-all state was devised for this study. |
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Authors:
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R E Hemphill; F D Pascoe; T Zabow |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde Volume: 49 ISSN: 0256-9574 ISO Abbreviation: S. Afr. Med. J. Publication Date: 1975 Nov |
Date Detail:
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Created Date: 1976-03-15 Completed Date: 1976-03-15 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0404520 Medline TA: S Afr Med J Country: SOUTH AFRICA |
Other Details:
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Languages: eng Pagination: 2121-5 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Adolescent Adult Aged Chronic Disease Clozapine / adverse effects, therapeutic use* Dibenzazepines / therapeutic use* Epilepsy / drug therapy Female Humans Male Middle Aged Recurrence Schizophrenia / drug therapy* Social Behavior Disorders / drug therapy* |
| Chemical | |
Reg. No./Substance:
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0/Dibenzazepines; 5786-21-0/Clozapine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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