Document Detail

An investigation on the antibacterial, cytotoxic and antibiofilm efficacy of starch-stabilized silver nanoparticles.
MedLine Citation:
PMID:  22115597     Owner:  NLM     Status:  Publisher    
The increased emergence of drug resistant microbes creates a major challenge to the scientific community for successful development of effective therapeutics. The antimicrobial activities of silver ions are well known, but limited information is available on the effects of green silver-nanoparticles(AgNPs) on human pathogens. In this work, we evaluated the antibacterial activity of starch-stabilized AgNPs against a panel of human pathogens commonly associated with air, water and food borne infections. The shape and size distribution of AgNPs were characterized by transmission electron microscopy. We showed that AgNPs were more effective against gram-positive and gram-negative pathogens as compared to acid-fast bacteria. AgNPs were not cytotoxic to macrophages at the bactericidal concentration and can augment intracellular killing potential of macrophages. Furthermore, we showed that AgNPs disrupt biofilm formation and exhibit better antibacterial activity compared to human cationic antimicrobial peptide LL-37. In summary, our data suggest AgNPs as a promising template for the design of novel antibacterial agents.
Soumitra Mohanty; Saswati Mishra; Prajna Jena; Biju Jacob; Biplab Sarkar; Avinash Sonawane
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-11-21
Journal Detail:
Title:  Nanomedicine : nanotechnology, biology, and medicine     Volume:  -     ISSN:  1549-9642     ISO Abbreviation:  -     Publication Date:  2011 Nov 
Date Detail:
Created Date:  2011-11-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101233142     Medline TA:  Nanomedicine     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011. Published by Elsevier Inc.
School of Biotechnology, KIIT University, Bhubaneswar , Orissa, India.
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