| The invertebrate odorant-binding protein LUSH is required for normal olfactory behavior in Drosophila. | |
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MedLine Citation:
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PMID: 11238251 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The invertebrate odorant-binding proteins consist of a large family of low-molecular-weight, highly divergent proteins expressed exclusively in the chemosensory sensilla of insects. Each member of this family studied to date is secreted into the sensillum lymph of a small subset of sensilla by non-neuronal support cells. These expression patterns suggests an odor-specific function for these proteins as opposed to a general role in sensillum biology. Consistent with this notion, mutants defective for LUSH, a Drosophila member of this family, have odor-specific defects in olfactory behavior. The Drosophila genome contains at least 32 members of this gene family, rivaling the number of odorant receptors in this species. The relationship between these two protein families and how they act to determine odor specificity of olfactory neurons will be the topic of future studies. |
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Authors:
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M S Kim; D P Smith |
Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Chemical senses Volume: 26 ISSN: 0379-864X ISO Abbreviation: Chem. Senses Publication Date: 2001 Feb |
Date Detail:
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Created Date: 2001-03-12 Completed Date: 2001-05-21 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 8217190 Medline TA: Chem Senses Country: England |
Other Details:
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Languages: eng Pagination: 195-9 Citation Subset: IM |
Affiliation:
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Department of Pharmacology and Center for Basic Neuroscience, University of Texas Southwestern Medical Center, Dallas 75390-9111, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Behavior, Animal / physiology Drosophila / genetics, physiology* Ethanol Female Genes, Insect Insect Proteins / genetics, physiology Male Mutation Odors Receptors, Odorant / genetics, physiology* Smell / genetics, physiology* |
| Grant Support | |
ID/Acronym/Agency:
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DC02539/DC/NIDCD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Insect Proteins; 0/Receptors, Odorant; 0/odorant-binding protein; 64-17-5/Ethanol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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