Document Detail


An inverse correlation of human peripheral blood regulatory T cell frequency with the disease activity of ulcerative colitis.
MedLine Citation:
PMID:  16614988     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Evidence suggests that CD4+CD25+ regulatory T cells play a crucial role in the suppression of intestinal inflammation. However, their role in the suppression of inflammatory bowel disease has not yet been addressed. We examined the proportion of regulatory T cells in inflammatory bowel disease. First, we isolated CD4+CD45RO+CD25+ T cells from the peripheral blood of healthy persons and showed that these cells suppressed T cell proliferation profoundly and expressed FoxP3 abundantly, revealing that they are regulatory cells. Then the proportion of CD45RO+CD25+ in peripheral blood CD4+ T cells was analyzed in patients and healthy controls by flow cytometry. CD4+CD45RO+CD25+ T cell frequency was significantly lower in active ulcerative colitis than in the control and inactive ulcerative colitis. CD4+CD45RO+CD25+ T cell frequency was inversely correlated with the clinical and endoscopic severity of ulcerative colitis. These results suggest that a deficiency of regulatory T cells is associated with the progression of ulcerative colitis.
Authors:
Makoto Takahashi; Kazuhiko Nakamura; Kuniomi Honda; Yousuke Kitamura; Takahiro Mizutani; Yuzuru Araki; Teppei Kabemura; Yoshiharu Chijiiwa; Naohiko Harada; Hajime Nawata
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Digestive diseases and sciences     Volume:  51     ISSN:  0163-2116     ISO Abbreviation:  Dig. Dis. Sci.     Publication Date:  2006 Apr 
Date Detail:
Created Date:  2006-04-14     Completed Date:  2006-05-26     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7902782     Medline TA:  Dig Dis Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  677-86     Citation Subset:  AIM; IM    
Affiliation:
Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Maidashi, Fukuoka, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Antigens, CD45 / immunology
Base Sequence
Biological Markers / analysis
CD4-Positive T-Lymphocytes / immunology
Case-Control Studies
Cells, Cultured
Colitis, Ulcerative / blood*,  physiopathology*
Disease Progression
Female
Humans
Male
Middle Aged
Molecular Sequence Data
Probability
Receptors, Interleukin-2 / immunology
Reference Values
Reverse Transcriptase Polymerase Chain Reaction
Sensitivity and Specificity
Severity of Illness Index
T-Lymphocytes, Regulatory / immunology*
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Receptors, Interleukin-2; EC 3.1.3.48/Antigens, CD45

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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