Document Detail

The invasive edge: invasion in colorectal cancer.
MedLine Citation:
PMID:  3720057     Owner:  NLM     Status:  MEDLINE    
Primary human colorectal carcinomas which had already metastasized to the draining lymph nodes have been studied by transmission electron microscopy and tissue culture. The invasive edges were identified by examining mirror-image blocks for light and electron microscopy. In the invasive edge there are single cells and small clusters of cells which have ultrastructural features suggestive of active cell movement; clusters of cells are found in the lymphatic trunks and in the subcapsular sinus of draining lymph nodes. Small clusters of cells survive in short-term culture; some of these cells are actively motile. These findings support the view that there is a sub-population of motile and invasive cells at the edge of human colorectal cancers.
I Carr; M Levy; P Watson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical & experimental metastasis     Volume:  4     ISSN:  0262-0898     ISO Abbreviation:  Clin. Exp. Metastasis     Publication Date:    1986 Apr-Jun
Date Detail:
Created Date:  1986-07-29     Completed Date:  1986-07-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8409970     Medline TA:  Clin Exp Metastasis     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  129-39     Citation Subset:  IM    
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MeSH Terms
Adenocarcinoma / pathology*,  ultrastructure
Cell Movement
Colonic Neoplasms / pathology*,  ultrastructure
Culture Techniques
Lymphatic Metastasis
Microscopy, Electron
Neoplasm Invasiveness / ultrastructure*
Rectal Neoplasms / pathology*,  ultrastructure

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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