| An intrinsic cell cycle checkpoint pathway mediated by MEK and ERK in Drosophila. | |
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MedLine Citation:
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PMID: 17011495 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cell cycle checkpoints are surveillance mechanisms that safeguard genome integrity. While the extrinsic pathways that halt the cell cycle in response to DNA damages have been well documented, the intrinsic pathways that ensure orderly progression of cell cycle events are not well understood. We demonstrate that Drosophila MEK and ERK constitute an essential intrinsic checkpoint pathway that restrains cell cycle progression in the absence of DNA damage and also responds to ionizing radiation to arrest the cell cycle. Embryos lacking MEK exhibit faster and extra division cycles and fail to undergo timely midblastula transition (MBT) or arrest following ionizing radiation. Conversely, constitutively activated MEK causes cell cycle arrest. Further, MEK activation in the early embryo is cell cycle-dependent and Raf independent and increases in response to ionizing radiation or in the absence of Chk1. Thus, MEK/ERK activation is required for multiple checkpoints and is essential for orderly cell cycle progression. |
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Authors:
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Vladic Mogila; Fan Xia; Willis X Li |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Developmental cell Volume: 11 ISSN: 1534-5807 ISO Abbreviation: Dev. Cell Publication Date: 2006 Oct |
Date Detail:
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Created Date: 2006-10-02 Completed Date: 2006-11-13 Revised Date: 2011-07-28 |
Medline Journal Info:
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Nlm Unique ID: 101120028 Medline TA: Dev Cell Country: United States |
Other Details:
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Languages: eng Pagination: 575-82 Citation Subset: IM |
Affiliation:
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Department of Biomedical Genetics, University of Rochester Medical Center, Rochester, New York 14642, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Cycle / physiology* Drosophila / embryology, genetics, metabolism*, radiation effects Embryo, Nonmammalian Enzyme Activation Gene Expression Regulation, Enzymologic Immunohistochemistry Kinetics Mitogen-Activated Protein Kinase Kinases / genetics, metabolism* Mitogen-Activated Protein Kinases / genetics, metabolism* Models, Biological RNA, Messenger / biosynthesis Radiation, Ionizing |
| Grant Support | |
ID/Acronym/Agency:
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R01 GM065774-05/GM/NIGMS NIH HHS; R01 GM077046-03/GM/NIGMS NIH HHS; R01GM077046/GM/NIGMS NIH HHS; R01GM65774/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/RNA, Messenger; EC 2.7.11.24/Mitogen-Activated Protein Kinases; EC 2.7.12.2/Mitogen-Activated Protein Kinase Kinases |
| Comments/Corrections | |
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