Document Detail


Is intrinsic aerobic exercise capacity a determinant of COPD susceptibility?
MedLine Citation:
PMID:  23353136     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Chronic obstructive pulmonary disease is a leading cause of morbidity and mortality, which is most commonly associated with smoking or exposure to environmental pollutants. Unfortunately, there is an inadequate understanding of the molecular and physiological determinants governing one's susceptibility for developing COPD. Here, we describe a novel hypothesis: Individuals with intrinsically low aerobic exercise capacity are more likely to develop COPD after exposure to key risk factors. The hypothesis is based on observations that aerobic exercise capacity is tightly associated with mortality across many complex diseases. The premise is supported by recent studies demonstrating that smokers who exercise regularly are less likely to develop or be hospitalized for COPD. Herein, we describe the evolutionary and molecular basis for this hypothesis and how it is a natural extension of previous theories explaining COPD susceptibility.
Authors:
Christopher S Stevenson; Liang Yew-Booth
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-23
Journal Detail:
Title:  Pulmonary pharmacology & therapeutics     Volume:  -     ISSN:  1522-9629     ISO Abbreviation:  Pulm Pharmacol Ther     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9715279     Medline TA:  Pulm Pharmacol Ther     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013. Published by Elsevier Ltd.
Affiliation:
Hoffmann-La Roche Inc., pRED, Pharma Research & Early Development, DTA Inflammation, 340 Kingsland Street, Nutley, United States, 07110; Imperial College London, Respiratory Pharmacology Group, Pharmacology and Toxicology Section, National Heart and Lung Institute, Centre for Integrative Mammalian Physiology and Pharmacology, London, UK SW7 2AZ; Centre for Respiratory Infections, Imperial College London, UK; University of Southern Denmark, Institute of Regional Health Services Research, Institute for Medical Biology, DK-5000 Odense C, Denmark. Electronic address: chirstopher.stevenson@roche.com.
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