Document Detail


The intravitreal penetration of orally administered ciprofloxacin in humans.
MedLine Citation:
PMID:  2071350     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To evaluate the penetration of ciprofloxacin, a new wide-spectrum oral antibiotic, into the vitreous, ciprofloxacin was administered orally to 21 patients who were scheduled to undergo vitreal surgery. Seven patients received 750 mg ciprofloxacin 4 hr before surgery (group I), seven patients received this dose 8 hr before surgery (group II), and seven patients received two 750-mg doses of oral ciprofloxacin every 12 hr. The last dose was administered 12 hr before surgery (group III). Vitreous and blood samples were collected simultaneously and assayed for ciprofloxacin concentrations by bioassay and high-performance liquid chromatography.
Authors:
G Keren; A Alhalel; E Bartov; R Kitzes-Cohen; E Rubinstein; S Segev; G Treister
Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Investigative ophthalmology & visual science     Volume:  32     ISSN:  0146-0404     ISO Abbreviation:  Invest. Ophthalmol. Vis. Sci.     Publication Date:  1991 Jul 
Date Detail:
Created Date:  1991-08-21     Completed Date:  1991-08-21     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7703701     Medline TA:  Invest Ophthalmol Vis Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2388-92     Citation Subset:  IM    
Affiliation:
Infectious Diseases Unit, Chaim Sheba Medical Center, Tel-Hashomer, Israel.
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Adolescent
Adult
Aged
Aged, 80 and over
Biological Assay
Chromatography, High Pressure Liquid
Ciprofloxacin / blood,  pharmacokinetics*
Drug Administration Schedule
Female
Humans
Male
Middle Aged
Premedication
Random Allocation
Retinal Diseases / surgery
Vitrectomy
Vitreous Body / metabolism*
Chemical
Reg. No./Substance:
85721-33-1/Ciprofloxacin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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