Document Detail

The intraoperative use of Amicar to reduce bleeding associated with open heart surgery.
MedLine Citation:
PMID:  7676769     Owner:  NLM     Status:  MEDLINE    
In an effort to reduce morbidity associated with transfusion of blood products, Amicar is used as a prophylactic inhibitor of hyperfibrinolysis associated with diffuse perioperative bleeding in patients undergoing open heart surgery. Previous studies indicate a significant reduction of intraoperative and postoperative bleeding in patients receiving Amicar during open heart surgery. Fifteen historical controls who did not receive Amicar were compared to 15 nonrandomized, prospective patients who received Amicar and who underwent open heart surgery by the same surgeon. The study found a significant reduction in postoperative chest tube output for the group receiving Amicar, as well as a reduction in perioperative blood product transfusion in patients who received Amicar. One patient in the Amicar group experienced a thrombotic event.
A E Aprile; T J Palmer
Related Documents :
18329459 - Bleeding in cardiac surgery: the use of aprotinin does not affect survival.
2478089 - High-dose aprotinin: hemostatic effects in open heart operations.
18416219 - Low molecular starch versus gelatin plasma expander during cpb: does it make a difference?
7676769 - The intraoperative use of amicar to reduce bleeding associated with open heart surgery.
19754679 - Aprotinin attenuates genomic expression variability following cardiac surgery.
11574339 - Normal saline versus lactated ringer's solution for intraoperative fluid management in ...
6289739 - Ceftriaxone (ro 13-9904) therapy of serious infection.
10934809 - Transrectal ultrasonographic findings in patients with hemospermia.
17674599 - Effect of time of day for urinary catheter removal on voiding behaviors in stroke patie...
Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  AANA journal     Volume:  63     ISSN:  0094-6354     ISO Abbreviation:  AANA J     Publication Date:  1995 Aug 
Date Detail:
Created Date:  1995-10-13     Completed Date:  1995-10-13     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0431420     Medline TA:  AANA J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  325-31     Citation Subset:  N    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
6-Aminocaproic Acid / therapeutic use*
Blood Loss, Surgical*
Blood Transfusion
Cardiac Surgical Procedures / adverse effects*
Chest Tubes
Intraoperative Care
Middle Aged
Prospective Studies
Reg. No./Substance:
60-32-2/6-Aminocaproic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  AANA journal course: update for nurse anesthetists--medical gases, hospital pipelines, and medical g...
Next Document:  Anesthesia for scoliosis: dwarfism and congenitally absent odontoid process.