Document Detail


The intraoperative use of Amicar to reduce bleeding associated with open heart surgery.
MedLine Citation:
PMID:  7676769     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In an effort to reduce morbidity associated with transfusion of blood products, Amicar is used as a prophylactic inhibitor of hyperfibrinolysis associated with diffuse perioperative bleeding in patients undergoing open heart surgery. Previous studies indicate a significant reduction of intraoperative and postoperative bleeding in patients receiving Amicar during open heart surgery. Fifteen historical controls who did not receive Amicar were compared to 15 nonrandomized, prospective patients who received Amicar and who underwent open heart surgery by the same surgeon. The study found a significant reduction in postoperative chest tube output for the group receiving Amicar, as well as a reduction in perioperative blood product transfusion in patients who received Amicar. One patient in the Amicar group experienced a thrombotic event.
Authors:
A E Aprile; T J Palmer
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  AANA journal     Volume:  63     ISSN:  0094-6354     ISO Abbreviation:  AANA J     Publication Date:  1995 Aug 
Date Detail:
Created Date:  1995-10-13     Completed Date:  1995-10-13     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0431420     Medline TA:  AANA J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  325-31     Citation Subset:  N    
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MeSH Terms
Descriptor/Qualifier:
6-Aminocaproic Acid / therapeutic use*
Aged
Blood Loss, Surgical*
Blood Transfusion
Cardiac Surgical Procedures / adverse effects*
Chest Tubes
Female
Humans
Intraoperative Care
Male
Middle Aged
Prospective Studies
Chemical
Reg. No./Substance:
60-32-2/6-Aminocaproic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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