| The intraoperative use of Amicar to reduce bleeding associated with open heart surgery. | |
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MedLine Citation:
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PMID: 7676769 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In an effort to reduce morbidity associated with transfusion of blood products, Amicar is used as a prophylactic inhibitor of hyperfibrinolysis associated with diffuse perioperative bleeding in patients undergoing open heart surgery. Previous studies indicate a significant reduction of intraoperative and postoperative bleeding in patients receiving Amicar during open heart surgery. Fifteen historical controls who did not receive Amicar were compared to 15 nonrandomized, prospective patients who received Amicar and who underwent open heart surgery by the same surgeon. The study found a significant reduction in postoperative chest tube output for the group receiving Amicar, as well as a reduction in perioperative blood product transfusion in patients who received Amicar. One patient in the Amicar group experienced a thrombotic event. |
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Authors:
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A E Aprile; T J Palmer |
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Publication Detail:
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Type: Clinical Trial; Controlled Clinical Trial; Journal Article |
Journal Detail:
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Title: AANA journal Volume: 63 ISSN: 0094-6354 ISO Abbreviation: AANA J Publication Date: 1995 Aug |
Date Detail:
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Created Date: 1995-10-13 Completed Date: 1995-10-13 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0431420 Medline TA: AANA J Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 325-31 Citation Subset: N |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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6-Aminocaproic Acid
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therapeutic use* Aged Blood Loss, Surgical* Blood Transfusion Cardiac Surgical Procedures / adverse effects* Chest Tubes Female Humans Intraoperative Care Male Middle Aged Prospective Studies |
| Chemical | |
Reg. No./Substance:
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60-32-2/6-Aminocaproic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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