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An intraoperative case of spontaneous restoration of circulation from asystole: a case of lazarus phenomenon.
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PMID:  23326710     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
This case report refers to a victim of intraoperative cardiac arrest, who restored spontaneous circulation despite of cessation of cardiopulmonary resuscitation (CPR). The victim, a 53-year-old man, was undergoing a surgical investigation and rehabilitation of a thigh hematoma. Two minutes after discontinuation of a 46 min CPR, a normotensive sinus node rhythm appeared at monitor. Despite of lack of an adequate explanation, the authors believe that the combination of the high total dose of adrenaline with the cessation of mechanical ventilation might augment venous return and lead to restoration of spontaneous circulation.
Authors:
Konstantinos A Ekmektzoglou; Eleni Koudouna; Eleni Bassiakou; Konstantinos Stroumpoulis; Phyllis Clouva-Molyvdas; Georgios Troupis; Theodoros Xanthos
Publication Detail:
Type:  Journal Article     Date:  2012-01-24
Journal Detail:
Title:  Case reports in emergency medicine     Volume:  2012     ISSN:  2090-648X     ISO Abbreviation:  Case Rep Emerg Med     Publication Date:  2012  
Date Detail:
Created Date:  2013-01-17     Completed Date:  2013-01-18     Revised Date:  2013-04-05    
Medline Journal Info:
Nlm Unique ID:  101591814     Medline TA:  Case Rep Emerg Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  380905     Citation Subset:  -    
Affiliation:
MSc Program in "Cardiopulmonary Resuscitation", School of Medicine, University of Athens, 75 Mikras Asias Street, 11527 Athens, Greece.
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Journal Information
Journal ID (nlm-ta): Case Rep Emerg Med
Journal ID (iso-abbrev): Case Rep Emerg Med
Journal ID (publisher-id): CRIM.EM
ISSN: 2090-648X
ISSN: 2090-6498
Publisher: Hindawi Publishing Corporation
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Copyright © 2012 Konstantinos A. Ekmektzoglou et al.
open-access:
Received Day: 9 Month: 10 Year: 2011
Accepted Day: 27 Month: 10 Year: 2011
Print publication date: Year: 2012
Electronic publication date: Day: 24 Month: 1 Year: 2012
Volume: 2012E-location ID: 380905
PubMed Id: 23326710
ID: 3542947
DOI: 10.1155/2012/380905

An Intraoperative Case of Spontaneous Restoration of Circulation from Asystole: A Case of Lazarus Phenomenon
Konstantinos A. Ekmektzoglou1*
Eleni Koudouna2
Eleni Bassiakou1
Konstantinos Stroumpoulis1
Phyllis Clouva-Molyvdas3
Georgios Troupis4
Theodoros Xanthos14
1MSc Program in “Cardiopulmonary Resuscitation”, School of Medicine, University of Athens, 75 Mikras Asias Street, 11527 Athens, Greece
2Department of Anaesthesiology, “Thriassio” General Hospital of Elefsina, Gennimata Avenue, 19600 Magoula, Greece
3Intensive Care Unit, “Thriassio” General Hospital of Elefsina, Gennimata Avenue, 19600 Magoula, Greece
4Department of Anatomy, School of Medicine, University of Athens, 75 Mikras Asias Street, 11527 Athens, Greece
Correspondence: *Konstantinos A. Ekmektzoglou: ekmektzo@hotmail.com
[other] Academic Editors: E. Kagawa and H. P. Wu

1. Introduction

The incidence of return of spontaneous circulation (ROSC) after discontinuation of cardiopulmonary resuscitation (CPR) might be one of the strongest evidence of medicine that ignorance is hiding behind myth. This phenomenon was named as Lazarus phenomenon in 1986 [1], although it had been reported for the first time many years earlier by Linko et al. [2]. The occurrence of this phenomenon is suspected to be frequent and underestimated [3].


2. Case Presentation

A man was dispatched in the emergency room by the Emergency Medical Service, after self-shooting himself. The patient was immediately transferred to the operating theatre, where he had undergone hemicolectomy, pericardiectomy, splenectomy, and left nephrectomy. After surgery, he was hospitalized in the Intensive Care Unit (ICU).

The weaning of the patient proved to be extremely difficult, leading to a thirty-day hospitalization in ICU; his morbid obesity (160 kg), his depression, and—of course—the complications of his initial critical illness, such as acute renal failure treated with haemodialysis, ischaemic stroke, and multiple infections, led to a prolonged ICU stay.

When attempts were made to cannulate the left femoral vein, a femoral hematoma was developed. Femoral artery rupture was diagnosed by ultrasound. The patient became haemodynamically unstable, while the monitor recorded sinus tachycardia. The patient was immediately transferred to the operating theatre for surgical restoration of the femoral artery. The left femoral venous catheter was removed and replaced by a right femoral venous catheter. A right femoral arterial catheter was also placed, in order to monitor the patient's blood pressure (BP) invasively. Despite continuous administration of fluids and noradrenaline, his BP remained low (BP = 75/32 mmHg).

Five minutes after the initiation of the surgical procedure, the patient's cardiac rhythm converted from a sinus tachycardia of 165 beats per minute (bpm) to a sinus bradycardia of 48 bpm and his arterial pressure wave decreased and finally disappeared. Cardiac arrest (CA) was diagnosed and the advanced life support algorithm was followed, with chest compressions, ventilation, and drug administration [4]. During CPR, the femoral artery was surgically repaired. Blood transfusion was discontinued when the patient's haemoglobin (Hb) was 10.2 mg/dL. The patient's oxygenation and the electrolytes did not show any abnormal values during resuscitation (Table 1).

The patient's diastolic pressure during chest compression varied from 11 mmHg to 24 mmHg (Figure 1). After 46 min of CPR, the bleeding had stopped, his Hb level had been normalized, and there was no other possible reversible cause of CA. The patient finally developed asystole. Two minutes after cessation of CPR, the rhythm changed to normal sinus (72 bpm) and a normotensive arterial wave (BP = 103/62 mmHg) appeared at the monitor.

No effort of spontaneous breathing was observed. After ROSC, the surgical wound closure continued, the patient was stabilized for 30 min and was transferred to ICU. During the patient's postresuscitation hospitalization in ICU, which lasted for 34 days before dying, his BP was preserved by noradrenaline infusion and no spontaneous breathing was self-attempted. In contrast, there was some neurological function present: spontaneous eye opening and movement. No other motor response was further achieved. His CT scan showed no other abnormalities except from a slight cerebral oedema.


3. Discussion

Lazarus phenomenon was first described in the international literature in 1982 and has been followed by a relatively small number of references through the past 30 years, considering the possible underestimation of the incidence [2, 3]. Due to legal concerns, underreporting of these cases is strongly suspected [3, 5]. Previous reports have tried to associate this phenomenon with various mechanisms or coincidences. More specifically, drug abuse, such as opioids and cocaine, has been associated with the phenomenon [6].

Hyperkalemia caused by renal failure might be related to the pathogenesis of CA and ROSC [7]. However, in other cases, authors support that increased venous return, after discontinuation of mechanical ventilation, might be responsible for the spontaneous restoration of circulation [8]. In addition to previous mechanisms, the increased total dose or delayed effect of adrenaline is possibly related [9]. Moreover, in a significant number of cases, the phenomenon occurred in an operating theatre, where blood gases analysis, mechanical ventilation, or drugs are easily available; furthermore, monitoring is obligatory and not immediately removed from patient [1012].

In our case, the victim spontaneously restored circulation from asystole, making it one of the most impressive reports of the phenomenon. This incidence occurred in an operating theatre; that is why circulation was detected with invasive BP measurement. The patient had also received an increased total dose of adrenaline (12 mg) during his prolonged CPR. His obesity was also responsible for autopositive end-expiratory pressure (PEEP) during mechanical ventilation impairing thus venous return, a factor that was reversed with discontinuation of mechanical ventilation. Moreover, acute renal failure was present in our patient and was combined with slight hyperkalemia in ROSC. Our patient's course of hospitalization was not different from cases described in the existing literature. Perhaps, one would claim that ROSC occurred after discontinuation of CPR, when fluid resuscitation was adequate. This is excluded from authors as an explanation, as efficacy of fluid resuscitation had been established by both physical and laboratory examination during CPR. Furthermore, the underlying rhythm was asystole.

What is obvious about our patient is that hypovolaemia resulted in CA. Moreover, if the hypovolaemia had not been reversed, no ROSC would have been achieved. The question remaining is what is the factor that needs to be activated or withdrawn, in order to permit spontaneous restoration of circulation? However, 10 min of monitoring after discontinuation of CPR is essential, in order to observe and study more this phenomenon.


References
1. Gamboa E,Bronsther O,Halasz N. The Lazarus phenomenonClinical TransplantsYear: 19861251273154376
2. Linko K,Honkavaara P,Salmenpera M. Recovery after discontinued cardiopulmonary resuscitationThe LancetYear: 198218263106107
3. Kämäräinen A,Virkkunen I,Holopainen L,Erkkilä EP,Yli-Hankala A,Tenhunen J. Spontaneous defibrillation after cessation of resuscitation in out-of-hospital cardiac arrest: a case of Lazarus phenomenonResuscitationYear: 200775354354617629389
4. International Liaison Committee on ResuscitationInternational consensus on cardiopulmonary resuscitation and emergency cardiovascular care science with treatment recommendations. Part 4: advanced life supportResuscitationYear: 2005672-321324716324990
5. Maeda H,Fujita MQ,Zhu BL,et al. Death following spontaneous recovery from cardiopulmonary arrest in a hospital mortuary: “Lazarus phenomenon” in a case of alleged medical negligenceForensic Science InternationalYear: 20021271-2828712098530
6. Walker A,McClelland H,Brenchley J. The Lazarus phenomenon following recreational drug useEmergency Medicine JournalYear: 2001181747511310473
7. Koblin DD. Prolonged asystolic hyperkalemic cardiac arrest with no neurologic sequelae: the Lazarus phenomenon arises againAnnals of Emergency MedicineYear: 19952545625637755795
8. Abdullah RS. Restoration of circulation after cessation of positive pressure ventilation in a case of “Lazarus syndrome”Anesthesia and AnalgesiaYear: 2001931p. 241
9. MacGillivray RG,Frolich MA. Spontaneous recovery after discontinuation of cardiopulmonary resuscitationAnesthesiologyYear: 199991258558610443636
10. Frolich MA. Spontaneous recovery after discontinuation of intraoperative cardiopulmonary resuscitation: case reportAnesthesiologyYear: 1998895125212539822016
11. Wiese CHR,Stojanovic T,Klockgether-Radke A,et al. Another case of “Lazarus phenomenon” during surgery? Spontaneous return of circulation in a patient with a pacemakerAnaesthesistYear: 200756121231123617898966
12. Fumeaux T,Borgeat A,Cuénoud PF,Erard A,de Werra P. Survival after cardiac arrest and severe acidosis (pH = 6.54)Intensive Care MedicineYear: 1997235p. 594

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