Document Detail


The intramuscular bioavailability of a phenylbutazone preparation in the horse.
MedLine Citation:
PMID:  8126767     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The plasma concentrations of phenylbutazone (PBZ) and its major metabolites, oxyphenbutazone (OPBZ) and gamma-OH-phenylbutazone (OHPBZ) were determined for up to 72 h in six horses, following intravenous (i.v.) and intramuscular (i.m.) administration of 4 g phenylbutazone, 20 ml Phenylarthrite Ventoquinol (Vetoquinol Spécialités Pharmaceutiques Vétérinaires, Magny-Vernois, 70200 Lure, France). After i.v. dosing the plasma disposition was best described by a two-compartment open model. The hydroxylated metabolites OPBZ and OHPBZ were present in detectable concentrations for 72 h and 48 h, respectively. After 36 h the OPBZ concentrations exceeded plasma PBZ concentrations. The plasma disposition following i.m. injection could be described by a one-compartment open model. The hydroxylated metabolites OPBZ and OHPBZ were present in detectable concentrations for 72 h and 36 h, respectively. Only after 72 h was the concentration of OPBZ in plasma higher than the concentration of PBZ. The mean i.m. bioavailability of phenylbutazone was calculated to be 91.7 +/- 10.1%.
Authors:
J Landuyt; F T Delbeke; M Debackere
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of veterinary pharmacology and therapeutics     Volume:  16     ISSN:  0140-7783     ISO Abbreviation:  J. Vet. Pharmacol. Ther.     Publication Date:  1993 Dec 
Date Detail:
Created Date:  1994-04-14     Completed Date:  1994-04-14     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7910920     Medline TA:  J Vet Pharmacol Ther     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  494-500     Citation Subset:  IM    
Affiliation:
Laboratory of Veterinary Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Ghent, Belgium.
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MeSH Terms
Descriptor/Qualifier:
Animals
Biological Availability
Horses / metabolism*
Injections, Intramuscular / veterinary
Injections, Intravenous / veterinary
Male
Muscles / metabolism*
Oxyphenbutazone / blood
Phenylbutazone / analogs & derivatives,  blood,  pharmacokinetics*
Chemical
Reg. No./Substance:
129-20-4/Oxyphenbutazone; 50-33-9/Phenylbutazone; 568-76-3/gamma-hydroxyphenylbutazone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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