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An intragastric balloon in the treatment of obese individuals with metabolic syndrome: A randomised controlled study.
MedLine Citation:
PMID:  23512773     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVE: There are limited controlled data for intragastric balloons (IGB) in obesity treatment. This randomised, controlled study evaluated the efficacy and safety of an IGB in obese individuals with metabolic syndrome (MS). DESIGN AND METHODS: 66 adults (BMI:30-40kg/m(2) ) were randomised to IGB for 6 months, with a 12 month behavioural modification (IGB Group;'IGBG'), or 12 month behavioural modification alone (Control Group;'CG'). The primary outcome was percentage change in body weight. RESULTS: 31 subjects (female:68%; mean age:43; mean BMI:36.0) were randomised to IGBG and 35 (66%;48;36.7) to CG. At 6 months, there was a significantly greater weight loss in the IGBG: -14.2 vs.-4.8;p<0.0001. This was associated with a significantly greater reduction in waist circumference, and an improvement in quality of life, with a trend for a larger %MS remission (50%vs.30%;n.s.). At month 12 the differences in weight loss were enduring: -9.2 vs.-5.2;p=0.007. Gastrointestinal-related adverse events were common in the IGBG, resolving predominantly within two weeks. The IGB was removed prematurely in 3 subjects (1 for refractory GI symptoms). CONCLUSIONS: Statistically significant and clinically relevant improvements in weight loss and health outcomes were observed with the IGBG at 6 months versus behavioural modification alone. The differential weight loss was still evident 6 months after IGB removal.
Authors:
Nicholas R Fuller; Suzanne Pearson; Namson S Lau; John Wlodarczyk; Michael B Halstead; Hoi-Poh Tee; Raman Chettiar; Arthur J Kaffes
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-3-20
Journal Detail:
Title:  Obesity (Silver Spring, Md.)     Volume:  -     ISSN:  1930-739X     ISO Abbreviation:  Obesity (Silver Spring)     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-3-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101264860     Medline TA:  Obesity (Silver Spring)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013 The Obesity Society.
Affiliation:
The Boden Institute, The University of Sydney, NSW, Australia. nick.fuller@sydney.edu.au.
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