Document Detail

The intraductal approach to breast cancer biomarker discovery.
MedLine Citation:
PMID:  16505441     Owner:  NLM     Status:  MEDLINE    
Established methods of breast cancer detection have well-described limitations, and new diagnostic techniques are evolving continually to improve diagnostic accuracy. The intraductal approach encompasses the modalities of nipple aspiration, ductal lavage, and duct endoscopy, and is a means of directly accessing the microenvironment of the breast and either sampling or visualizing this intraductal milieu. The aim of sampling this mammary microenvironment is to obtain samples from the physical surroundings of cells that are undergoing malignant transformation, thereby providing a new method of detection before the development of a clinically or radiologically discernible mass. A literature review was conducted to investigate the evolution of the intraductal approach and its particular application in the field of biomarker discovery, primarily using the intraductal technique of nipple aspiration, in combination with emerging protein profiling techniques.
R Sascha Dua; Clare M Isacke; Gerald P H Gui
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of clinical oncology : official journal of the American Society of Clinical Oncology     Volume:  24     ISSN:  1527-7755     ISO Abbreviation:  J. Clin. Oncol.     Publication Date:  2006 Mar 
Date Detail:
Created Date:  2006-02-28     Completed Date:  2006-03-16     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  8309333     Medline TA:  J Clin Oncol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1209-16     Citation Subset:  IM    
Department of Academic Surgery (Breast Unit), Royal Marsden National Health Service Foundation Trust, London, United Kingdom.
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MeSH Terms
Angiogenesis Inducing Agents / analysis
Biopsy, Fine-Needle* / instrumentation,  methods
Breast Neoplasms / chemistry*,  genetics,  pathology*
Carcinoembryonic Antigen / analysis
Cell Transformation, Neoplastic / chemistry
Chromosomal Instability
DNA Methylation
Endoscopy / methods
Equipment Design
Kallikreins / analysis
Loss of Heterozygosity
Mammary Glands, Human / chemistry*,  pathology
Neoplasm Proteins / analysis*
Receptor, erbB-2 / analysis
Receptors, Cell Surface / analysis
Receptors, Urokinase Plasminogen Activator
Sensitivity and Specificity
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
Tumor Markers, Biological / analysis*
Reg. No./Substance:
0/Angiogenesis Inducing Agents; 0/Carcinoembryonic Antigen; 0/Neoplasm Proteins; 0/PLAUR protein, human; 0/Receptors, Cell Surface; 0/Receptors, Urokinase Plasminogen Activator; 0/Tumor Markers, Biological; EC, erbB-2; EC 3.4.21.-/Kallikreins

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