| The intraductal approach to breast cancer biomarker discovery. | |
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MedLine Citation:
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PMID: 16505441 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Established methods of breast cancer detection have well-described limitations, and new diagnostic techniques are evolving continually to improve diagnostic accuracy. The intraductal approach encompasses the modalities of nipple aspiration, ductal lavage, and duct endoscopy, and is a means of directly accessing the microenvironment of the breast and either sampling or visualizing this intraductal milieu. The aim of sampling this mammary microenvironment is to obtain samples from the physical surroundings of cells that are undergoing malignant transformation, thereby providing a new method of detection before the development of a clinically or radiologically discernible mass. A literature review was conducted to investigate the evolution of the intraductal approach and its particular application in the field of biomarker discovery, primarily using the intraductal technique of nipple aspiration, in combination with emerging protein profiling techniques. |
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Authors:
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R Sascha Dua; Clare M Isacke; Gerald P H Gui |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Journal of clinical oncology : official journal of the American Society of Clinical Oncology Volume: 24 ISSN: 1527-7755 ISO Abbreviation: J. Clin. Oncol. Publication Date: 2006 Mar |
Date Detail:
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Created Date: 2006-02-28 Completed Date: 2006-03-16 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 8309333 Medline TA: J Clin Oncol Country: United States |
Other Details:
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Languages: eng Pagination: 1209-16 Citation Subset: IM |
Affiliation:
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Department of Academic Surgery (Breast Unit), Royal Marsden National Health Service Foundation Trust, London, United Kingdom. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Angiogenesis Inducing Agents
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analysis Biopsy, Fine-Needle* / instrumentation, methods Breast Neoplasms / chemistry*, genetics, pathology* Carcinoembryonic Antigen / analysis Cell Transformation, Neoplastic / chemistry Chromosomal Instability DNA Methylation Endoscopes Endoscopy / methods Equipment Design Female Humans Irrigation Kallikreins / analysis Loss of Heterozygosity Mammary Glands, Human / chemistry*, pathology Neoplasm Proteins / analysis* Nipples Proteomics Receptor, erbB-2 / analysis Receptors, Cell Surface / analysis Receptors, Urokinase Plasminogen Activator Sensitivity and Specificity Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Tumor Markers, Biological / analysis* |
| Chemical | |
Reg. No./Substance:
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0/Angiogenesis Inducing Agents; 0/Carcinoembryonic Antigen; 0/Neoplasm Proteins; 0/PLAUR protein, human; 0/Receptors, Cell Surface; 0/Receptors, Urokinase Plasminogen Activator; 0/Tumor Markers, Biological; EC 2.7.10.1/Receptor, erbB-2; EC 3.4.21.-/Kallikreins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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