Document Detail


The intracorporeal autoorganic biofilter of portal blood in portal hypertension surgery.
MedLine Citation:
PMID:  11462919     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND/AIMS: The authors present the new surgical treatment method for portal hypertension by means of intracorporeal autoorganic biofilter of portal blood at the portosystemic shunt pathway. The hepatized spleen is used as the organic biofilter of portal blood. METHODOLOGY: The experiments were carried out on 20 mongrel dogs, both sexes, 18-20 kg of body weight. The animals were divided into the four equal groups. The comparative evaluation of portal hypertension treatment efficiency by means of several vascular portosystemic shunts were performed after the portal hypertension modeling. On the animals of groups I and II, the mesenterico-caval and splenorenal shunts were performed, respectively. The hepatized autospleen was involved in the portosystemic shunt pathway in the animals of group III. The animals of group IV served as controls. RESULTS: The reduction in perfusional pressure of the blood which flows to the liver led to damage of the organ's functional possibilities, significant disturbances to the hemodynamics and reduction of the liver detoxification possibilities, respectively, for several portocaval shunt creations during the portal hypertension model. On the other hand, the undetoxificated portal blood entrance into the system blood flow via the created shunt over the liver increased. CONCLUSIONS: The hepatized autospleen insertion into the portosystemic bloodflow gave us the opportunity to perform the dosage passing of portal blood into the systemic bloodflow and to maintain the pressure of the portal blood, which flows to the liver. Moreover, the hepatized autospleen has shown such specific liver functions as glucogenesis, albumin synthesis and others.
Authors:
Z Kakabadze; L Benashvili; E Berishvili
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Hepato-gastroenterology     Volume:  48     ISSN:  0172-6390     ISO Abbreviation:  Hepatogastroenterology     Publication Date:    2001 May-Jun
Date Detail:
Created Date:  2001-07-20     Completed Date:  2002-01-16     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8007849     Medline TA:  Hepatogastroenterology     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  752-6     Citation Subset:  IM    
Affiliation:
Organs and Tissues Preservation and Transplantation Laboratory, Tbilisi Medical Academy, 33 Chavchavadze Ave, 380079, Tbilisi, Georgia.
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MeSH Terms
Descriptor/Qualifier:
Animals
Decompression, Surgical
Disease Models, Animal
Dogs
Female
Hepatocytes / transplantation*
Hypertension, Portal / surgery*
Liver Function Tests
Liver Transplantation / methods*
Male
Portasystemic Shunt, Surgical / methods*
Spleen / surgery*
Transplantation, Autologous
Transplantation, Heterotopic / methods*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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