Document Detail


The intracellular redox state is a core determinant of mitochondrial fusion.
MedLine Citation:
PMID:  22945481     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Mitochondrial hyperfusion has recently been shown to function as a cellular stress response, providing transient protection against apoptosis and mitophagy. However, the mechanisms that mediate this response remain poorly understood. In this study, we demonstrate that oxidized glutathione (GSSG), the core cellular stress indicator, strongly induces mitochondrial fusion. Biochemical and functional experiments show that GSSG induces the generation of disulphide-mediated mitofusin oligomers, in a process that also requires GTP hydrolysis. Our data outline the molecular events that prime the fusion machinery, providing new insights into the coupling of mitochondrial fusion with the cellular stress response.
Authors:
Timothy Shutt; Michèle Geoffrion; Ross Milne; Heidi M McBride
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-09-04
Journal Detail:
Title:  EMBO reports     Volume:  13     ISSN:  1469-3178     ISO Abbreviation:  EMBO Rep.     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-01     Completed Date:  2013-01-30     Revised Date:  2013-10-09    
Medline Journal Info:
Nlm Unique ID:  100963049     Medline TA:  EMBO Rep     Country:  England    
Other Details:
Languages:  eng     Pagination:  909-15     Citation Subset:  IM    
Affiliation:
University of Ottawa Heart Institute, Ottawa, Ontario, Canada.
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MeSH Terms
Descriptor/Qualifier:
Cytosol / enzymology,  metabolism
GTP Phosphohydrolases / metabolism
Glutathione Disulfide / metabolism*
Guanosine Triphosphate / metabolism
HeLa Cells
Humans
Hydrolysis
Mitochondrial Dynamics*
Mitochondrial Proteins / metabolism
Oxidation-Reduction
Oxidative Stress*
Grant Support
ID/Acronym/Agency:
43935//Canadian Institutes of Health Research
Chemical
Reg. No./Substance:
0/Mitochondrial Proteins; 27025-41-8/Glutathione Disulfide; 86-01-1/Guanosine Triphosphate; EC 3.6.1.-/GTP Phosphohydrolases; EC 3.6.1.-/MFN2 protein, human
Comments/Corrections
Comment In:
EMBO Rep. 2012 Oct;13(10):870-1   [PMID:  22964759 ]

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