Document Detail


The intestine as a possible target for fumonisin toxicity.
MedLine Citation:
PMID:  17642075     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Fumonisins constitute a family of toxic and carcinogenic mycotoxins produced by Fusarium verticillioides (formerly F. moniliforme), a common fungal contaminant of corn. Contamination with fumonisin B(1) (FB(1)) is of concern as this mycotoxin causes various animal diseases. The gastrointestinal tract represents the first barrier against ingested chemicals, food contaminants, and natural toxins. Following ingestion of fumonisin-contaminated food or feed, intestinal epithelial cells could be exposed to a high concentration of toxin. In this review, we have summarized the data dealing with the impact of FB(1) on the intestine. Although FB(1 )is poorly absorbed and metabolized in the intestine, it induces intestinal disturbances (abdominal pain or diarrhea) and causes extra-intestinal organ pathologies (pulmonary edema, leukoencephalomalacia, or neural tube defects). The main toxicological effect of FB(1) reported in vivo and in vitro is the accumulation of sphingoid bases associated with the depletion of complex sphingolipids. This disturbance of the sphingolipid biosynthesis pathway could explain the other observed toxicological effects such as an alteration in intestinal epithelial cell viability and proliferation, a modification of cytokine production, and a modulation of intestinal physical barrier function.
Authors:
Sandrine Bouhet; Isabelle P Oswald
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Molecular nutrition & food research     Volume:  51     ISSN:  1613-4125     ISO Abbreviation:  Mol Nutr Food Res     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-08-16     Completed Date:  2007-11-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101231818     Medline TA:  Mol Nutr Food Res     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  925-31     Citation Subset:  IM    
Affiliation:
Laboratoire de Pharmacologie-Toxicologie, INRA, Toulouse, France.
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MeSH Terms
Descriptor/Qualifier:
Animal Feed
Animals
Cell Division / drug effects
Cell Survival / drug effects
Cytokines / biosynthesis
Food Contamination
Fumonisins / pharmacokinetics,  toxicity*
Intestinal Absorption
Intestinal Diseases / chemically induced,  pathology,  physiopathology
Intestines / drug effects*,  pathology,  physiopathology
Sphingolipids / biosynthesis
Tissue Distribution
Chemical
Reg. No./Substance:
0/Cytokines; 0/Fumonisins; 0/Sphingolipids; 116355-83-0/fumonisin B1

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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