| The intestinal microbiome of infants and the use of probiotics. | |
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MedLine Citation:
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PMID: 21415831 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE OF REVIEW: The increasing use of probiotics in neonates deserves scrutiny of the therapeutic as well as potentially harmful effects of these bacteria. In this review we describe the possible application of probiotics in the more common diseases in the neonatal period. RECENT FINDINGS: Recent advances in our capability to identify microbes and their function in the gastrointestinal tract offer exciting opportunities to discover the pathophysiology of enigmatic diseases such as necrotizing enterocolitis (NEC) and late-onset sepsis (LOS) in the neonate. The relationship of the resident intestinal microbes to neural and muscular processes such as intestinal motility and neurodevelopment are also being evaluated. SUMMARY: We focus on the possibility of the application of probiotics for disorders of motility in the infant, NEC and LOS. Here we will summarize some of the recent advances in these areas as they relate to clinical practice and discuss areas where additional research is needed. |
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Authors:
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Flavia Indrio; Josef Neu |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Current opinion in pediatrics Volume: 23 ISSN: 1531-698X ISO Abbreviation: Curr. Opin. Pediatr. Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-03-18 Completed Date: 2011-07-26 Revised Date: 2013-02-15 |
Medline Journal Info:
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Nlm Unique ID: 9000850 Medline TA: Curr Opin Pediatr Country: United States |
Other Details:
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Languages: eng Pagination: 145-50 Citation Subset: IM |
Affiliation:
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University of Bari, Bari, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Enteric Nervous System
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physiology Enterocolitis, Necrotizing / microbiology, therapy* Gastrointestinal Motility / physiology Humans Infant, Newborn Infant, Premature Infant, Premature, Diseases / microbiology, therapy Intestinal Mucosa / microbiology Intestines / microbiology*, physiology Metagenome* Probiotics / therapeutic use* Sepsis / microbiology, therapy* |
| Grant Support | |
ID/Acronym/Agency:
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R01 HD059143/HD/NICHD NIH HHS; R01 HD059143-03/HD/NICHD NIH HHS |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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