Document Detail


The intestinal microbiome of infants and the use of probiotics.
MedLine Citation:
PMID:  21415831     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE OF REVIEW: The increasing use of probiotics in neonates deserves scrutiny of the therapeutic as well as potentially harmful effects of these bacteria. In this review we describe the possible application of probiotics in the more common diseases in the neonatal period.
RECENT FINDINGS: Recent advances in our capability to identify microbes and their function in the gastrointestinal tract offer exciting opportunities to discover the pathophysiology of enigmatic diseases such as necrotizing enterocolitis (NEC) and late-onset sepsis (LOS) in the neonate. The relationship of the resident intestinal microbes to neural and muscular processes such as intestinal motility and neurodevelopment are also being evaluated.
SUMMARY: We focus on the possibility of the application of probiotics for disorders of motility in the infant, NEC and LOS. Here we will summarize some of the recent advances in these areas as they relate to clinical practice and discuss areas where additional research is needed.
Authors:
Flavia Indrio; Josef Neu
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Current opinion in pediatrics     Volume:  23     ISSN:  1531-698X     ISO Abbreviation:  Curr. Opin. Pediatr.     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-03-18     Completed Date:  2011-07-26     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  9000850     Medline TA:  Curr Opin Pediatr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  145-50     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Enteric Nervous System / physiology
Enterocolitis, Necrotizing / microbiology,  therapy*
Gastrointestinal Motility / physiology
Humans
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases / microbiology,  therapy
Intestinal Mucosa / microbiology
Intestines / microbiology*,  physiology
Metagenome*
Probiotics / therapeutic use*
Sepsis / microbiology,  therapy*
Grant Support
ID/Acronym/Agency:
R01 HD059143/HD/NICHD NIH HHS; R01 HD059143-03/HD/NICHD NIH HHS
Comments/Corrections
Erratum In:
Curr Opin Pediatr. 2014 Feb;26(1):136

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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