Document Detail

The intestinal bacterial colonisation in preterm infants: a review of the literature.
MedLine Citation:
PMID:  16677741     Owner:  NLM     Status:  MEDLINE    
The aim of this study is to review the normal development of the intestinal microflora of preterm infants and the factors influencing its development. Preterm infants have an increased intestinal permeability, which may lead to bacterial translocation to systemic organs and tissues. In combination with immaturity of the immune system the risk to systemic infections might be increased. Especially potential pathogenic bacteria are able to translocate. The intestinal microflora of breast-fed term infants, dominated by bifidobacteria and lactobacilli, is thought to suppress the growth of potentially pathogenic bacteria. Many attemps have been made to stimulate the presence of bifidobacteria and lactobacilli with changes in the diet and ingredients-like prebiotics and probiotics. After selection, six studies were included reviewing the intestinal bacterial colonisation of preterm infants. In general, these studies show that the intestinal bacterial colonisation with beneficial bacteria is delayed in preterm infants. The number of potentially pathogenic bacteria is high. Antibiotics influence the intestinal colonisation. Many preterm infants receive prophylactic antibiotics at birth. As antibiotics delay the normal intestinal colonisation, caution should be given to the treatment with broadspectrum antibiotics in preterm infants at birth and every attempt has to be made to restrict the period of treatment.
Elisabeth A M Westerbeek; Anemone van den Berg; Harrie N Lafeber; Jan Knol; Willem P F Fetter; Ruurd M van Elburg
Publication Detail:
Type:  Journal Article; Review     Date:  2006-05-04
Journal Detail:
Title:  Clinical nutrition (Edinburgh, Scotland)     Volume:  25     ISSN:  0261-5614     ISO Abbreviation:  Clin Nutr     Publication Date:  2006 Jun 
Date Detail:
Created Date:  2006-06-16     Completed Date:  2006-11-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8309603     Medline TA:  Clin Nutr     Country:  England    
Other Details:
Languages:  eng     Pagination:  361-8     Citation Subset:  IM    
Department of Pediatrics, Subdivision of Neonatology, VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands.
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MeSH Terms
Anti-Bacterial Agents / adverse effects
Bacteria / growth & development*
Bacterial Translocation
Bacteroides / growth & development
Bifidobacterium / growth & development
Breast Feeding
Clostridium / growth & development
Delivery, Obstetric / methods
Escherichia coli / growth & development
Infant, Newborn
Infant, Premature*
Intestines / microbiology*
Klebsiella / growth & development
Lactobacillus / growth & development
Pseudomonas / growth & development
Staphylococcus / growth & development
Streptococcus / growth & development
Reg. No./Substance:
0/Anti-Bacterial Agents

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