Document Detail


The intestinal absorption of cadmium increases during a common viral infection (coxsackie virus B3) in mice.
MedLine Citation:
PMID:  9630849     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Murine intestinal absorption, tissue accumulation and redistribution of 109Cd during infection were studied using the common human virus Coxsackie virus B3 (CB3) adapted to the mouse. Female Balb/c mice were infected with CB3 and, on day 4 of the infection, dosed orally with 0.3 or 750 microgram Cd/kg body weight, with 109Cd as a tracer, in order to study intestinal absorption and tissue distribution of Cd during infection (Experiment 1). Other mice were dosed with 0.3 microgram Cd/kg body weight 3 days before being infected and, on day 4 of the infection, Cd redistribution was studied (Experiment 2). In both experiments non-infected control animals received the same treatment as infected animals. Results showed that the infected animals had a higher gastrointestinal absorption of Cd than noninfected animals when Cd was administered during infection. In the infected animals the absorption at the low Cd dosage was increased by 70% and was tripled at the high dosage. The increased absorption enhanced the accumulation of Cd in all organs studied. Moreover, the infection caused a Cd dose-dependent change in the organ distribution of Cd, when Cd was administered during the infection. However, no redistribution of previously accumulated Cd occurred during ongoing disease, indicating that Cd was not mobilised from body stores by the infection. These results show, for the first time, that an invading micro-organism can increase the intestinal absorption and concomitantly alter the tissue distribution of an environmental pollutant (Cd) if exposure occurs during the course of viral infection.
Authors:
A W Glynn; Y Lind; E Funseth; N G Ilbäck
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Chemico-biological interactions     Volume:  113     ISSN:  0009-2797     ISO Abbreviation:  Chem. Biol. Interact.     Publication Date:  1998 May 
Date Detail:
Created Date:  1998-07-06     Completed Date:  1998-07-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0227276     Medline TA:  Chem Biol Interact     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  79-89     Citation Subset:  IM    
Affiliation:
Toxicology Division, National Food Administration, Uppsala, Sweden. glwi@slv.se
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MeSH Terms
Descriptor/Qualifier:
Administration, Oral
Animals
Body Weight
Cadmium / administration & dosage,  pharmacokinetics*,  toxicity
Coxsackievirus Infections / metabolism*,  pathology
Enterovirus B, Human*
Environmental Pollutants / administration & dosage,  pharmacokinetics,  toxicity
Female
Humans
Intestinal Absorption*
Mice
Mice, Inbred BALB C
Organ Size
Tissue Distribution
Chemical
Reg. No./Substance:
0/Environmental Pollutants; 7440-43-9/Cadmium

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