| An interventional magnetic resonance imaging technique for the molecular characterization of intraprostatic dynamic contrast enhancement. | |
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MedLine Citation:
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PMID: 15967127 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The biological characterization of an individual patient's tumor by noninvasive imaging will have an important role in cancer care and clinical research if the molecular processes that underlie the image data are known. Spatial heterogeneity in the dynamics of magnetic resonance imaging contrast enhancement (DCE-MRI) is hypothesized to reflect variations in tumor angiogenesis. Here we demonstrate the feasibility of precisely colocalizing DCE-MRI data with the genomic and proteomic profiles of underlying biopsy tissue using a novel MRI-guided biopsy technique in a patients with prostate cancer. |
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Authors:
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Cynthia Ménard; Robert C Susil; Peter Choyke; Jonathan Coleman; Robert Grubb; Ahmed Gharib; Axel Krieger; Peter Guion; David Thomasson; Karen Ullman; Sandeep Gupta; Virginia Espina; Lance Liotta; Emanuel Petricoin; Gabor Fitchtinger; Louis L Whitcomb; Ergin Atalar; C Norman Coleman; Kevin Camphausen |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Molecular imaging Volume: 4 ISSN: 1535-3508 ISO Abbreviation: Mol Imaging Publication Date: 2005 Jan-Mar |
Date Detail:
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Created Date: 2005-06-21 Completed Date: 2005-10-18 Revised Date: 2012-03-15 |
Medline Journal Info:
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Nlm Unique ID: 101120118 Medline TA: Mol Imaging Country: United States |
Other Details:
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Languages: eng Pagination: 63-6 Citation Subset: IM |
Affiliation:
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National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Biopsy Contrast Media Humans Image Enhancement / methods Magnetic Resonance Imaging / methods* Male Prostatic Neoplasms / pathology* RNA, Neoplasm / isolation & purification |
| Grant Support | |
ID/Acronym/Agency:
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R01 EB 002963/EB/NIBIB NIH HHS; R01 EB002963-05/EB/NIBIB NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 0/RNA, Neoplasm |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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