Document Detail

An interstitial light assembly for photodynamic therapy in prostatic carcinoma.
MedLine Citation:
PMID:  10532979     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To develop an interstitial laser light delivery system using multiple optical fibres for photodynamic therapy (PDT) in the treatment of prostate cancer. PATIENTS AND METHODS: A laser beam was divided equally with a 1 x 4 fibre splitter to deliver PDT simultaneously through four 2-cm long, flexible cylindrical optical diffusers. Biplanar transrectal ultrasonography (TRUS) and a template were used to position the optical fibres percutaneously. In vivo measurements of light penetration depth (1/micro[eff] ) in prostate tissue were made in seven patients, using a sheathed isoprobe to measure light fluence rates at varying radial distances from the diffuser. The prostate was fixed with stabilization needles to minimize displacement during needle placement. RESULTS: The mean (sd, range) micro(eff) in the prostates of the seven patients was 0.35 (0.07, 0.22-0.44) mm-1, which produced closely parallel slopes of light attenuation. However, there was up to a 10-fold variation in absolute light levels at the same diffuser-detector separation distances amongst the seven patients, probably caused by blood pooling around the diffuser light source. A similar problem around the isoprobe detector was overcome by sheathing the probe in clear plastic tubing. By stabilizing the prostate, the optical fibre positioning was precise to within 2 mm. CONCLUSION: Although this light delivery and TRUS assembly were developed for clinical PDT in the prostate, the same instrumentation can be used reliably for in vivo light-penetration studies. Haemorrhage was unpredictable and highlighted one of the main problems which needs to be overcome.
L K Lee; C Whitehurst; M L Pantelides; J V Moore
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  BJU international     Volume:  84     ISSN:  1464-4096     ISO Abbreviation:  BJU Int.     Publication Date:  1999 Nov 
Date Detail:
Created Date:  1999-12-22     Completed Date:  1999-12-22     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  100886721     Medline TA:  BJU Int     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  821-6     Citation Subset:  IM    
Laser Oncology Programme, CRC Department of Experimental Radiation Oncology, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester, UK.
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MeSH Terms
Equipment Design
Fiber Optic Technology / instrumentation
Laser Therapy*
Photochemotherapy / instrumentation,  methods*
Prostatic Neoplasms / drug therapy*

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