Document Detail

On the interstitial fibrotic changes in acute and convalescent myocarditis obtained by serial endomyocardial biopsy.
MedLine Citation:
PMID:  3831395     Owner:  NLM     Status:  MEDLINE    
In order to determine the characteristics of the interstitial fibrotic change of the myocardium in cases with viral or idiopathic myocarditis, right ventricular endomyocardial biopsy findings in 9 cases where serial endomyocardial biopsy had been performed at the acute (5-10 days after the onset of the disease), subacute (11-21 days) and convalescent stages (22-167 days) and in 1 case at the acute stage were analyzed. They were then compared with right ventricular endomyocardial biopsy findings from 58 cases with chronic right ventricular overloading and which were of various kinds of congenital and valvular heart diseases. The following results were obtained: Interstitial fibrosis was seen at the acute stage along with an increase in fibroblasts, macrophages and lymphocytes. An analysis of the interstitial changes revealed that, at the acute stage, thin collagenous fibers were prominent as well as interstitial edema and at the convalescent stage, the edema became less prominent and instead, thick collagenous fibers increased. Comparison with the 58 cases with chronic right ventricular overloading revealed that diffuse and/or subendocardial fibrosis and endocardial thickening were more frequent and statistically more significant in cases with myocarditis.
Z X Yu; M Sekiguchi; M Hiroe; M Hasumi; S Morimoto; K Hirosawa
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Japanese circulation journal     Volume:  49     ISSN:  0047-1828     ISO Abbreviation:  Jpn. Circ. J.     Publication Date:  1985 Dec 
Date Detail:
Created Date:  1986-05-13     Completed Date:  1986-05-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7806868     Medline TA:  Jpn Circ J     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  1270-6     Citation Subset:  IM    
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MeSH Terms
Acute Disease
Endocarditis / pathology
Fibroblasts / pathology
Heart Ventricles / pathology
Macrophages / pathology
Myocarditis / pathology*
Myocardium / pathology*

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