Document Detail

The interrelationships between electrical stimulation, the environment surrounding the vascular endothelial cells of the skin, and the role of nitric oxide in mediating the blood flow response to electrical stimulation.
MedLine Citation:
PMID:  17767118     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Electrical stimulation (ES) is a commonly used modality in physical therapy for treating wounds such as diabetic ulcers and pressure sores but the mechanism of its effect on skin blood flow (BF) has not been determined. MATERIAL/METHODS: Ten subjects were examined during ES of the skin above the quadriceps muscle with biphasic sine wave stimulation at a frequency of 30 Hertz, pulse width 250 microseconds. BF was measured between the electrodes with a Laser Doppler Flow meter. In one series of experiments, N-Nitro-L-Arginine Methyl Ester (L-NAME) was infused to determine the effect of blocking nitric oxide production on the blood flow response to ES. In another series, acetylcholine and epinephrine were infused to determine the effects of the initial blood flow prior to stimulation on the magnitude of the BF response to ES. RESULTS: The apparent mechanism of the increase in blood flow during electrical stimulation seems to be mediated by nitric oxide since the increase in blood flow as a result of stimulation was blocked by L-NAME. Modulation of the vasoconstrictor or vasodilator tone of the skin blood vessels altered the magnitude of the BF response to electrical stimulation; epinephrine blocked the response and acetylcholine increased the response. CONCLUSIONS: The BF response to ES is caused by NO and can be modulated by changing the environment of the vascular endothelial cell.
Jerrold Petrofsky; Colleen Maloney Hinds; Jennifer Batt; Michelle Prowse; Hye Jin Suh
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Medical science monitor : international medical journal of experimental and clinical research     Volume:  13     ISSN:  1234-1010     ISO Abbreviation:  Med. Sci. Monit.     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-09-03     Completed Date:  2007-11-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9609063     Medline TA:  Med Sci Monit     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  CR391-397     Citation Subset:  IM    
Department of Physical Therapy, Loma Linda University, Loma Linda, CA 92350, USA.
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MeSH Terms
Acetylcholine / pharmacology
Electric Stimulation
Endothelial Cells / metabolism*
Epinephrine / pharmacology
NG-Nitroarginine Methyl Ester / pharmacology
Nitric Oxide / metabolism*
Regional Blood Flow
Skin / blood supply*,  metabolism*
Reg. No./Substance:
10102-43-9/Nitric Oxide; 50903-99-6/NG-Nitroarginine Methyl Ester; 51-43-4/Epinephrine; 51-84-3/Acetylcholine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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