Document Detail

The interpretation of uterine artery pulsatility index in normal and hypertensive pregnancy.
MedLine Citation:
PMID:  12797128     Owner:  NLM     Status:  PubMed-not-MEDLINE    
The Doppler flow velocity pulsatility index (PI) of the uteroplacental vascular bed is of debatable value for the interpretation of hemodynamic changes, when these are due both to pathological alterations in the vasculature, as in mild pre-eclampsia, and to physiological adjustments to vasoactive substances. The aim of this study was to apply a mathematical model, which includes maternal pulse pressure and mean arterial pressure, to the PI and to investigate whether this formula would add information with respect to discrimination between normal women and those with mild or severe pre-eclampsia. The subjects were patients with mild (n = 41) and severe (n = 34) pre-eclampsia and, as a control group, healthy pregnant women (n = 46). The uterine artery PI was studied by spectral Doppler analyses and compared to a P(z) value, theoretically representing a 'back pressure' in the uteroplacental circulation. Additionally, P(z) values were computed from earlier data concerning the dynamic circulatory effects of dihydralazine and acute volume expansion. The basal PI was significantly higher in the severely pre-eclamptic patients but not in the mildly pre-eclamptic patients compared to the controls. However, the P(z) was significantly higher in patients with both mild (p < 0.001) and severe pre-eclampsia (p < 0.0001) compared to the normal group. In the severely pre-eclamptic patients receiving dihydralazine, the P(z) tended to decrease (p = 0.07), in contrast to the volume-expansion group where P(z) was unaffected by the procedure. In conclusion, it seems that including measurement of the mean arterial pressure and pulse pressure with the PI adds valuable information about the circulatory status in this particular vasculature, regarding both 'basal' values and hemodynamic changes.
C Grunewald; M Kublickas; H Nisell; L Nylund; M Westgren
Related Documents :
14568738 - Birthweight, childhood social class, and change in adult blood pressure in the 1946 bri...
9383168 - Sex differences in awareness and control of hypertension in france.
1468818 - Microalbuminuria and other cardiovascular risk factors in nondiabetic subjects.
3578398 - Retrospective comparison of blood pressure course during preeclamptic and matched contr...
7976258 - Pressure increase following primary laser trabeculoplasty. effect on the visual field.
21088918 - Baroreflex analysis in diabetes mellitus: linear and nonlinear approaches.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology     Volume:  4     ISSN:  0960-7692     ISO Abbreviation:  Ultrasound Obstet Gynecol     Publication Date:  1994 Nov 
Date Detail:
Created Date:  2003-06-10     Completed Date:  2003-10-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9108340     Medline TA:  Ultrasound Obstet Gynecol     Country:  England    
Other Details:
Languages:  eng     Pagination:  476-9     Citation Subset:  -    
Copyright Information:
Copyright 1994 International Society of Ultrasound in Obstetrics and Gynecology
Department of Obstetrics and Gynecology, Huddinge University Hospital, Huddinge, Sweden.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Maternal hyperoxygenation in the treatment of mild intrauterine growth retardation: a pilot study.
Next Document:  Effect of standing on non-pregnant uterine blood flow.