Document Detail

On the interpretation and use of <|E|2>(d*) profiles.
MedLine Citation:
PMID:  14747698     Owner:  NLM     Status:  MEDLINE    
Profiles of squared normalized structure factors, <|E|(2)>(d*), have been computed for a large number of proteins and nucleic acids. These are interpreted in terms of their underlying structural features. It is also shown that the 'solvent dip' at around 6.3 A resolution is to a large extent a protein secondary-structure effect that is enhanced by the water structure. A hierarchical classification of protein structures based on their <|E|(2)>(d*) profiles is briefly outlined, together with the use of <|E|(2)>(d*) profiles as an improvement over Wilson absolute scale estimation and as a novel solvent-modelling method.
Richard J Morris; Eric Blanc; Gérard Bricogne
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Publication Detail:
Type:  Journal Article     Date:  2004-01-23
Journal Detail:
Title:  Acta crystallographica. Section D, Biological crystallography     Volume:  60     ISSN:  0907-4449     ISO Abbreviation:  Acta Crystallogr. D Biol. Crystallogr.     Publication Date:  2004 Feb 
Date Detail:
Created Date:  2004-01-28     Completed Date:  2004-10-08     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9305878     Medline TA:  Acta Crystallogr D Biol Crystallogr     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  227-40     Citation Subset:  IM    
Global Phasing Ltd, Sheraton House, Castle Park, Cambridge CB3 0AX, England.
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MeSH Terms
Cluster Analysis
Crystallography, X-Ray / methods
Models, Statistical
Nucleic Acids / chemistry*
Protein Conformation
Protein Structure, Secondary
Proteins / chemistry*
Solvents / chemistry
Statistics as Topic / methods*
Water / chemistry
Reg. No./Substance:
0/Nucleic Acids; 0/Proteins; 0/Solvents; 7732-18-5/Water

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