Document Detail


The interpretation of bloodspot 17 alpha-hydroxyprogesterone levels in term and pre-term neonates.
MedLine Citation:
PMID:  3767291     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Bloodspot 17 alpha-hydroxyprogesterone, plasma cortisol, plasma sodium and urinary 17 alpha-hydroxyprogesterone, cortisol, sodium and creatinine levels were determined in 24 term and 32 pre-term infants on the third, eighth and fourteenth days of life. Pre-term infants, whether 'well' or 'sick', had significantly raised bloodspot 17 alpha-hydroxyprogesterone levels (up to 158 nmol/L) compared with those found in term infants (up to 18.8 nmol/L). Urinary 17 alpha-hydroxyprogesterone creatinine ratios were also higher in pre-term infants. Plasma cortisol results showed similar ranges for term and pre-term infants, and bloodspot 17 alpha-hydroxyprogesterone/plasma cortisol ratios for day 3 specimens correlated with the degree of prematurity. These results may be due either to immature enzyme systems in the pre-term baby or to an excess of related steroids cross-reacting in the 17 alpha-hydroxyprogesterone assay. We propose the use of two distinct upper limits of normal of 20 nmol/L (term infants) and 200 nmol/L (pre-term infants), for the interpretation of bloodspot 17 alpha-hydroxyprogesterone levels at the end of the first week of life.
Authors:
J Berry; P Betts; P J Wood
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of clinical biochemistry     Volume:  23 ( Pt 5)     ISSN:  0004-5632     ISO Abbreviation:  Ann. Clin. Biochem.     Publication Date:  1986 Sep 
Date Detail:
Created Date:  1986-11-13     Completed Date:  1986-11-13     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0324055     Medline TA:  Ann Clin Biochem     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  546-51     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
17-alpha-Hydroxyprogesterone
Humans
Hydrocortisone / blood
Hydroxyprogesterones / blood*
Infant, Newborn
Infant, Premature / blood*
Infant, Premature, Diseases / blood
Sodium / blood,  urine
Chemical
Reg. No./Substance:
0/Hydroxyprogesterones; 50-23-7/Hydrocortisone; 68-96-2/17-alpha-Hydroxyprogesterone; 7440-23-5/Sodium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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