Document Detail

The interplay between DSL proteins and ubiquitin ligases in Notch signaling.
MedLine Citation:
PMID:  16093323     Owner:  NLM     Status:  MEDLINE    
Lateral inhibition is a pattern refining process that generates single neural precursors from a field of equipotent cells and is mediated via Notch signaling. Of the two Notch ligands Delta and Serrate, only the former was thought to participate in this process. We now show that macrochaete lateral inhibition involves both Delta and Serrate. In this context, Serrate interacts with Neuralized, a ubiquitin ligase that was heretofore thought to act only on Delta. Neuralized physically associates with Serrate and stimulates its endocytosis and signaling activity. We also characterize a mutation in mib1, a Drosophila homolog of mind bomb, another Delta-targeting ubiquitin ligase from zebrafish. Mib1 affects the signaling activity of Delta and Serrate in both lateral inhibition and wing dorsoventral boundary formation. Simultaneous absence of neuralized and mib1 completely abolishes Notch signaling in both aforementioned contexts, making it likely that ubiquitination is a prerequisite for Delta/Serrate signaling.
Chrysoula Pitsouli; Christos Delidakis
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-08-10
Journal Detail:
Title:  Development (Cambridge, England)     Volume:  132     ISSN:  0950-1991     ISO Abbreviation:  Development     Publication Date:  2005 Sep 
Date Detail:
Created Date:  2005-08-26     Completed Date:  2006-03-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8701744     Medline TA:  Development     Country:  England    
Other Details:
Languages:  eng     Pagination:  4041-50     Citation Subset:  IM    
Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology Hellas, Heraklion, Greece.
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MeSH Terms
Body Patterning / genetics,  physiology*
Calcium-Binding Proteins / metabolism*
Cell Differentiation / physiology
Cells, Cultured
Databases, Genetic
Drosophila Proteins / genetics,  metabolism*
Intercellular Signaling Peptides and Proteins
Membrane Proteins / metabolism*
Nervous System / cytology,  embryology*
Receptors, Notch / metabolism*
Signal Transduction / physiology*
Ubiquitin-Protein Ligases / genetics,  metabolism*
Reg. No./Substance:
0/Calcium-Binding Proteins; 0/Drosophila Proteins; 0/Intercellular Signaling Peptides and Proteins; 0/Membrane Proteins; 0/Receptors, Notch; 0/delta protein; 0/notch protein, Drosophila; 134324-36-0/Serrate proteins; EC bomb protein, Drosophila; EC Ligases; EC protein, Drosophila

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