| An internet-based "kinetic imaging system" (KIS) for MicroPET. | |
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MedLine Citation:
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PMID: 16132473 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Many considerations, involving understanding and selection of multiple experimental parameters, are required to perform MicroPET studies properly. The large number of these parameters/variables and their complicated interdependence make their optimal choice nontrivial. We have a developed kinetic imaging system (KIS), an integrated software system, to assist the planning, design, and data analysis of MicroPET studies. The system serves multiple functions-education, virtual experimentation, experimental design, and image analysis of simulated/experimental data-and consists of four main functional modules--"Dictionary," "Virtual Experimentation," "Image Analysis," and "Model Fitting." The "Dictionary" module provides didactic information on tracer kinetics, pharmacokinetic, MicroPET imaging, and relevant biological/pharmacological information. The "Virtual Experimentation" module allows users to examine via computer simulations the effect of biochemical/pharmacokinetic parameters on tissue tracer kinetics. It generates dynamic MicroPET images based on the user's assignment of kinetics or kinetic parameters to different tissue organs in a 3-D digital mouse phantom. Experimental parameters can be adjusted to investigate the design options of a MicroPET experiment. The "Image Analysis" module is a full-fledged image display/manipulation program. The "Model Fitting" module provides model-fitting capability for measured/simulated tissue kinetics. The system can be run either through the Web or as a stand-alone process. With KIS, radiotracer characteristics, administration method, dose level, imaging sequence, and image resolution-to-noise tradeoff can be evaluated using virtual experimentation. KIS is designed for biology/pharmaceutical scientists to make learning and applying tracer kinetics fun and easy. |
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Authors:
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Sung-Cheng Huang; David Truong; Hsiao-Ming Wu; Arion F Chatziioannou; Weber Shao; Anna M Wu; Michael E Phelps |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging Volume: 7 ISSN: 1536-1632 ISO Abbreviation: Mol Imaging Biol Publication Date: 2005 Sep-Oct |
Date Detail:
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Created Date: 2006-02-23 Completed Date: 2006-03-14 Revised Date: 2010-12-28 |
Medline Journal Info:
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Nlm Unique ID: 101125610 Medline TA: Mol Imaging Biol Country: United States |
Other Details:
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Languages: eng Pagination: 330-41 Citation Subset: IM |
Affiliation:
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Department of Molecular and Medical Pharmacology, UCLA David Geffen School of Medicine, University of California in Los Angeles, CA 90095, USA. hhuang@mednet.ucla.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Imaging, Three-Dimensional / instrumentation*, methods* Internet* Kinetics Mice Positron-Emission Tomography / instrumentation*, methods* Software |
| Grant Support | |
ID/Acronym/Agency:
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R24 CA092865-06/CA/NCI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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