Document Detail

An intermediate in the biosynthesis of vasopressin and neurophysin in the guinea pig posterior pituitary.
MedLine Citation:
PMID:  6633958     Owner:  NLM     Status:  MEDLINE    
Biosynthesis of oxytocin (OT), vasopressin (AVP) and neurophysins (NP) has been studied in the guinea pig using incorporation of radiolabelled cysteine and fucose, and analysis by high pressure liquid chromatography and radioimmunoassay. Using these methods it was possible to identify and quantitate OT, AVP and their respective NPs as well as the carboxy-terminal glycopeptide derived from the AVP precursor. In addition, we have also identified an intermediate component comprising the AVP-related NP with its carboxy-terminal glycopeptide still attached. The presence of this intermediate suggests that the removal of AVP is the first step in the proteolytic cleavage of the AVP precursor.
I C Robinson; P M Jones
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neuroscience letters     Volume:  39     ISSN:  0304-3940     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  1983 Sep 
Date Detail:
Created Date:  1983-12-20     Completed Date:  1983-12-20     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  273-8     Citation Subset:  IM    
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MeSH Terms
Chromatography, High Pressure Liquid
Electrophoresis, Polyacrylamide Gel
Guinea Pigs / metabolism*
Neurophysins / biosynthesis*
Oxytocin / metabolism
Pituitary Gland, Posterior / metabolism*
Vasopressins / biosynthesis*
Reg. No./Substance:
0/Neurophysins; 11000-17-2/Vasopressins; 50-56-6/Oxytocin

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