| The interleukin-36 receptor pathway regulates Aspergillus fumigatus-induced Th1 and Th17 responses. | |
| | |
MedLine Citation:
|
PMID: 23147407 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
IL-1 drives T-helper responses, particularly Th17, in host defense. Sharing the same co-receptor, the IL-1 family member IL-36 exhibits properties similar to those of IL-1. In the present study, we investigated the role of IL-36 in Aspergillus fumigatus-induced human T-helper cell responses. We observed that different morphological forms of A. fumigatus variably increase steady-state mRNA of IL-36 subfamily members. IL-36α is not significantly induced by any morphological form of Aspergillus. Most strikingly, IL-36γ is significantly induced by live A. fumigatus conidia and heat killed hyphae, whereas IL-36Ra is significantly induced by heat killed conidia, hyphae and live conidia. We also observed that IL-36γ expression is dependent on the dectin-1/Syk and TLR4 signaling pathway. In contrast, TLR2 and CR3 inhibit IL-36γ expression. The biological relevance of IL-36 induction by Aspergillus is demonstrated by experiments showing that inhibition of the IL-36 receptor by IL-36Ra reduces Aspergillus-induced IL-17 and IFN-γ. These data describe that IL-36-dependent signals are a novel cytokine pathway that regulates T-helper responses induced by A. fumigatus, and demonstrate a role for TLR4 and dectin-1 in the induction of IL-36γ. |
| | |
Authors:
|
Mark S Gresnigt; Berenice Rösler; Cor W M Jacobs; Katharina L Becker; Leo A B Joosten; Jos W M van der Meer; Mihai G Netea; Charles A Dinarello; Frank L van de Veerdonk |
Related Documents
:
|
22998457 - Hiv+ viremic slow progressors maintain low regulatory t-cell numbers in rectal mucosa b... 23001547 - Time limited immunomodulatory functions of transplanted neural precursor cells. 15749387 - Hydroxytyrosol, a natural antioxidant from olive oil, prevents protein damage induced b... 23573417 - Heat shock proteins and regulatory t cells. 22732277 - Hypercapnic acidosis attenuates ventilation-induced lung injury by a nuclear factor-κb... 16098827 - Identification of sh2-b as a key regulator of leptin sensitivity, energy balance, and b... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2012-11-12 |
Journal Detail:
|
Title: European journal of immunology Volume: - ISSN: 1521-4141 ISO Abbreviation: Eur. J. Immunol. Publication Date: 2012 Nov |
Date Detail:
|
Created Date: 2012-11-13 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 1273201 Medline TA: Eur J Immunol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
© 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
Affiliation:
|
Department of Medicine, Radboud University Nijmegen Medical Centre and Nijmegen Institute for Infection, Inflammation, and Immunity (N4i), Nijmegen, the Netherlands. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Bipolar versus Monopolar Transurethral Resection of the Prostate: Results of a Comparative, Prospect...
Next Document: Epidermal Growth Factor Receptor Transactivation Is Necessary for Glucagon-Like Peptide-1 to Protect...